Role of polyphenols and other phytochemicals on molecular signaling

S Upadhyay, M Dixit - Oxidative medicine and cellular longevity, 2015 - Wiley Online Library
Optimized nutrition through supplementation of diet with plant derived phytochemicals has
attracted significant attention to prevent the onset of many chronic diseases including …

Halophytes as source of bioactive phenolic compounds and their potential applications

M Lopes, A Sanches-Silva, M Castilho… - Critical Reviews in …, 2023 - Taylor & Francis
Halophytes are salt-tolerant plants that inhabit environments in which they are exposed to
extreme stress, wherefore they exhibit conserved and divergent metabolic responses …

Nrf2—a promising therapeutic target for defensing against oxidative stress in stroke

R Zhang, M Xu, Y Wang, F Xie, G Zhang, X Qin - Molecular Neurobiology, 2017 - Springer
Stroke is one of the leading causes of death and disability in the world. Oxidative stress,
which refers to an excessive generation of reactive oxygen species (ROS), plays a key role …

From cocoa to chocolate: Effect of processing on flavanols and methylxanthines and their mechanisms of action

L Goya, JE Kongor, S de Pascual-Teresa - International Journal of …, 2022 - mdpi.com
Despite the health benefits associated with the ingestion of the bioactive compounds in
cocoa, the high concentrations of polyphenols and methylxanthines in the raw cocoa beans …

Therapeutic application of betalains: A review

E Madadi, S Mazloum-Ravasan, JS Yu, JW Ha… - Plants, 2020 - mdpi.com
Anthocyanins, betalains, riboflavin, carotenoids, chlorophylls and caramel are the basic
natural food colorants used in modern food manufacture. Betalains, which are composed of …

Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression

JH Lee, TO Khor, L Shu, ZY Su, F Fuentes… - Pharmacology & …, 2013 - Elsevier
Reactive metabolites from carcinogens and oxidative stress can drive genetic mutations,
genomic instability, neoplastic transformation, and ultimately carcinogenesis. Numerous …

Signaling pathways involved in paraquat-induced pulmonary toxicity: Molecular mechanisms and potential therapeutic drugs

X Liu, H Yang, Z Liu - International Immunopharmacology, 2022 - Elsevier
Paraquat poisoning is a severe health problem globally, particularly in developing countries.
Due to its severe toxicity, the mortality rate of paraquat poisoning is greatly higher than other …

Multiple regulations of Keap1/Nrf2 system by dietary phytochemicals

S Qin, DX Hou - Molecular nutrition & food research, 2016 - Wiley Online Library
Keap1/Nrf2 system plays a critical role on cellular protection by regulating many antioxidant
and detoxification enzyme genes through the antioxidant response element (ARE). Thus, it …

A protective role of the NRF2‐Keap1 pathway in maintaining intestinal barrier function

Z Wen, W Liu, X Li, W Chen, Z Liu… - … medicine and cellular …, 2019 - Wiley Online Library
Nrf2 (NF‐E2‐related factor 2) is a master regulator of cellular oxidative levels against
environmental stresses. Nrf2 induces the expression of metabolic detoxification and …

Polyphenols and non-alcoholic fatty liver disease: impact and mechanisms

I Rodriguez-Ramiro, D Vauzour… - Proceedings of the …, 2016 - cambridge.org
Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic component of the
metabolic syndrome and its prevalence is rapidly increasing due to its strong association …