Abstract Calcium ion (Ca 2+) cycle plays a crucial role in the contraction and relaxation of
cardiomyocytes. The sarcoplasmic reticulum (SR) acts as an organelle for storing Ca 2+ …

Cardiac sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA2a) plays a central role in
myocardial contractility. SERCA2a actively transports Ca2+ into the SR and regulates …

The role of skeletal muscle in nonshivering thermogenesis (NST) is not well understood.
Here we show that sarcolipin (Sln), a newly identified regulator of the sarco/endoplasmic …

Cardiac cells mature in the first postnatal week, concurrent with altered extracellular
mechanical properties. To investigate the effects of extracellular stiffness on cardiomyocyte …

Alterations of protein folding or Ca2+ levels within the endoplasmic reticulum (ER) result in
the unfolded-protein response (UPR), a process considered as an endogenous inducer of …

Stress cardiomyopathy, also referred to as Takotsubo cardiomyopathy, transient apical
ballooning or broken heart syndrome, is a disorder associated with transient left ventricular …

The Notch signaling pathway has been demonstrated to play a critical role during
mammalian cardiac development based on recent findings from gene-targeted mice. In …

We describe a sensitive mRNA profiling technology, PMAGE (for “polony multiplex analysis
of gene expression”), which detects messenger RNAs (mRNAs) as rare as one transcript per …

Context Echocardiographic measures of left ventricular (LV) structure and function are
heritable phenotypes of cardiovascular disease. Objective To identify common genetic …

The serine-threonine kinases Pim-1 and Akt regulate cellular proliferation and survival.
Although Akt is known to be a crucial signaling protein in the myocardium, the role of Pim-1 …