Mutations in the type I keratin 16 (Krt16) and its partner type II keratin 6 (Krt6a, Krt6b) cause
pachyonychia congenita (PC), a disorder typified by dystrophic nails, painful hyperkeratotic …

Epithelial-mesenchymal transition (EMT) is characterized by loss of cell-cell junctions,
polarity and epithelial markers, and in turn, acquisition of mesenchymal features and motility …

Psoriasis vulgaris is characterized by hyperproliferation and incomplete terminal
differentiation of epidermal keratinocytes. Despite the established role of Wnt pathways in …

Keratins are a family of intermediate filament-forming proteins highly specific to epithelial
cells. A combination of expressed keratin genes is a defining property of the epithelium …

Background Activation of telomerase is a critical and late event in tumor progression. Thus,
in patients with adult-T cell leukaemia (ATL), an HTLV-1 (Human T cell Leukaemia virus type …

Pachyonychia congenita (PC) is a rare keratinizing disorder characterized by painful
palmoplantar keratoderma for which there is no standard current treatment. PC is caused by …

Background The identification of key target nodes within complex molecular networks
remains a common objective in scientific research. The results of pathway analyses are …

We previous reported that Sp1 recruits c-Jun to the promoter of the 12 (S)-lipoxygenase
gene in 12-myristate 13-acetate-treated cells. We now show that Sp1 that recruited HDAC1 …

Abstract Background Chronic Fatigue Syndrome (CFS), Persian Gulf War Illness (PGI), and
fibromyalgia are overlapping symptom complexes without objective markers or known …

Biopharmaceuticals that target specific disease-mediating molecules have advanced our
understanding of the pathogenesis of psoriasis. The traditional paradigm that psoriasis is …