Like all retroviruses, the human immunodeficiency virus selectively packages two copies of
its unspliced RNA genome, both of which are utilized for strand-transfer-mediated …

Publisher Summary This chapter focuses on recent biochemical and biophysical studies that
examine the nucleic acid chaperone function of HIV‐1 nucleocapsid protein (NC) and its …

Aptamers consist of short oligonucleotides that bind specific targets. They provide
advantages over antibodies, including robustness, low cost, and reusability. Their chemical …

The HIV-1 nucleocapsid protein (NC) is a nucleic acid chaperone, which remodels nucleic
acid structures so that the most thermodynamically stable conformations are formed. This …

One salient feature of reverse transcription in retroviruses, notably in the human
immunodeficiency virus type 1, is that it requires the homologous nucleocapsid (NC) protein …

Human immunodeficiency virus type 1 (HIV-1) and other retroviruses replicate through
reverse transcription, a process in which the single stranded RNA of the viral genome is …

The nucleocapsid protein (NC) of human immunodeficiency virus type 1 (HIV-1) has two zinc
fingers, each containing the invariant metal ion binding residues CCHC. Recent reports …

The role of nucleocapsid protein (NC) in the early steps of retroviral replication appears
largely that of a facilitator for reverse transcription and integration. Using a wide variety of …

Reverse transcription is a critical step in the life cycle of all retroviruses and related
retrotransposons. This complex process is performed exclusively by the retroviral reverse …

The nucleocapsid protein (NC) of HIV type 1 is a nucleic acid chaperone that facilitates the
rearrangement of nucleic acids into conformations containing the maximum number of …