Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

Aging is defined as a progressive time‐related accumulation of changes responsible for or
at least involved in the increased susceptibility to disease and death. The brain seems to be …

Age, apolipoprotein E ε4 (APOE) and chromosomal sex are well-established risk factors for
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …

Neurological diseases are recognized as major causes of disability and mortality worldwide.
Due to the dynamic progress of diseases such as Alzheimer's disease (AD), Parkinson's …

The peri-menopause or menopausal transition—the time period that surrounds the final
years of a woman's reproductive life—is associated with profound reproductive and …

Metabolic dysfunction is a well-established feature of Alzheimer's disease (AD), evidenced
by brain glucose hypometabolism that can be observed potentially decades prior to the …

Aging is an inevitable biological process characterized by a progressive decline in
physiological function and increased susceptibility to disease. The detrimental effects of …

Perimenopause is a midlife transition state experienced by women that occurs in the context
of a fully functioning neurological system and results in reproductive senescence. Although …

Aging is the leading risk factor for several age-associated diseases such as
neurodegenerative diseases. Understanding the biology of aging mechanisms is essential …