Osteoarthritis (OA) is one of the most debilitating diseases and is associated with a high
personal and socioeconomic burden. So far, there is no therapy available that effectively …

An increasing body of evidence highlights the strong potential for a diet rich in fruit and
vegetables to delay, and often prevent, the onset of chronic diseases, including …

Glucosinolates (GLS) and their derivatives are secondary plant metabolites abundant in
Brassicaceae. Due to the enzymatic reaction between GLS and myrosinase enzyme …

Progerin, a truncated unprocessed lamin A protein, causes tissue aging and degeneration.
In this study we explored the role of progerin in the pathogenesis of intervertebral disc …

Osteoarthritis (OA) is the most common joint disorder in the world and is the most frequent
cause of walking related disability among older adults in the US, which brings a significant …

Diabetes and cardiometabolic disorders such as hypertension and obesity are major risk
factors for the development of cardiovascular disease, with a wealth of evidence suggesting …

Osteoarthritis (OA) therapy remains a large challenge since no causative treatment options
are so far available. Despite some main pathways contributing to OA are identified its …

Sulforaphane, the native but unstable form of SFX-01, is an antioxidant that activates the
NRF2 and inhibits the NF-KB pathways to achieve its actions. Resolving the mechanism (s) …

Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an important transcription factor that plays
a pivotal role in cellular defense against oxidative injury. Nrf2 signaling is involved in …

Previous studies have demonstrated that sulforaphane (SFN) is a promising agent against
osteoclastic bone destruction. However, the mechanism underlying its anti-osteoclastogenic …