Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection
LCK Bell, M Noursadeghi - Nature Reviews Microbiology, 2018 - nature.com
Co-infection with Mycobacterium tuberculosis is the leading cause of death in individuals
infected with HIV-1. It has long been known that HIV-1 infection alters the course of M …
infected with HIV-1. It has long been known that HIV-1 infection alters the course of M …
The gut microbiome as a biomarker of differential susceptibility to SARS-CoV-2
Coronavirus disease 2019 (COVID-19) continues to exact a devastating global toll.
Ascertaining the factors underlying differential susceptibility and prognosis following viral …
Ascertaining the factors underlying differential susceptibility and prognosis following viral …
Activation-induced pyroptosis contributes to the loss of MAIT cells in chronic HIV-1 infected patients
P Xia, XD Xing, CX Yang, XJ Liao, FH Liu… - Military Medical …, 2022 - Springer
Background Mucosal-associated invariant T (MAIT) cells are systemically depleted in human
immunodeficiency virus type 1 (HIV-1) infected patients and are not replenished even after …
immunodeficiency virus type 1 (HIV-1) infected patients and are not replenished even after …
Hyper-Expression of PD-1 Is Associated with the Levels of Exhausted and Dysfunctional Phenotypes of Circulating CD161++TCR iVα7.2+ Mucosal-Associated …
Mucosal-associated invariant T (MAIT) cells, defined as CD161++ TCR iVα7. 2+ T cells, play
an important role in the innate defense against bacterial infections, and their functionality is …
an important role in the innate defense against bacterial infections, and their functionality is …
[HTML][HTML] Human MAIT cells exit peripheral tissues and recirculate via lymph in steady state conditions
Mucosal-associated invariant T cells (MAIT cells) recognize bacterial metabolites as antigen
and are found in blood and tissues, where they are poised to contribute to barrier immunity …
and are found in blood and tissues, where they are poised to contribute to barrier immunity …
Sustained IFN-I stimulation impairs MAIT cell responses to bacteria by inducing IL-10 during chronic HIV-1 infection
X Tang, S Zhang, Q Peng, L Ling, H Shi, Y Liu… - Science …, 2020 - science.org
Mucosal-associated invariant T (MAIT) cells in HIV-1–infected individuals are functionally
impaired by poorly understood mechanisms. Single-cell transcriptional and surface protein …
impaired by poorly understood mechanisms. Single-cell transcriptional and surface protein …
MAIT cells are functionally impaired in a Mauritian cynomolgus macaque model of SIV and Mtb co-infection
AL Ellis, AJ Balgeman, EC Larson, MA Rodgers… - PLoS …, 2020 - journals.plos.org
Mucosal-associated invariant T (MAIT) cells can recognize and respond to some bacterially
infected cells. Several in vitro and in vivo models of Mycobacterium tuberculosis (Mtb) …
infected cells. Several in vitro and in vivo models of Mycobacterium tuberculosis (Mtb) …
Roles, function and relevance of LAG3 in HIV infection
CG Graydon, AL Balasko, KR Fowke - PLoS pathogens, 2019 - journals.plos.org
HIV causes several forms of immune dysfunction that need to be addressed in a functional
cure for HIV. Immune exhaustion describes a dysfunctional phenotype caused by chronic …
cure for HIV. Immune exhaustion describes a dysfunctional phenotype caused by chronic …
Mucosal‐associated invariant T cells: A cryptic coordinator in HIV‐infected immune reconstitution
B Su, D Kong, X Yang, T Zhang… - Journal of Medical …, 2022 - Wiley Online Library
Human immunodeficiency virus type 1 (HIV‐1) infection causes considerable morbidity and
mortality worldwide. Although antiretroviral therapy (ART) has largely transformed HIV …
mortality worldwide. Although antiretroviral therapy (ART) has largely transformed HIV …
Mucosal-associated invariant T (MAIT) cells provide B-cell help in vaccinated and subsequently SIV-infected Rhesus Macaques
Mucosal-associated invariant T (MAIT) cells help combat opportunistic infections. Thus,
MAIT cells are of interest in HIV/SIV vaccination and infection. We investigated MAIT cell …
MAIT cells are of interest in HIV/SIV vaccination and infection. We investigated MAIT cell …