Angiogenic signaling pathways and anti-angiogenic therapy for cancer

ZL Liu, HH Chen, LL Zheng, LP Sun… - Signal transduction and …, 2023 - nature.com
Angiogenesis, the formation of new blood vessels, is a complex and dynamic process
regulated by various pro-and anti-angiogenic molecules, which plays a crucial role in tumor …

A concise review of VEGF, PDGF, FGF, Notch, angiopoietin, and HGF signalling in tumor angiogenesis with a focus on alternative approaches and future directions

S Vimalraj - International Journal of Biological Macromolecules, 2022 - Elsevier
Angiogenesis forms new vessels from existing ones. Abnormal angiogenesis, which is what
gives tumor microenvironments their distinctive features, is characterised by convoluted …

VEGF signaling: Role in angiogenesis and beyond

P Shaw, SKD Dwivedi, R Bhattacharya… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Angiogenesis is a crucial process for tissue development, repair, and tumor survival.
Vascular endothelial growth factor (VEGF) is a key driver secreted by cancer cells …

Changing landscape of anti-angiogenic therapy: Novel approaches and clinical perspectives

RN Gacche - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Targeting angiogenesis has remained one of the important aspects in disease biology in
general and cancer in particular. Currently (June 2023), over 593 clinical trials have been …

The role of non-coding RNAs in the diagnosis of different stages (HCC, CHB, OBI) of hepatitis B infection

O Gholizadeh, S Akbarzadeh, M Moein… - Microbial …, 2023 - Elsevier
Despite the availability of an effective hepatitis B virus (HBV) vaccine and universal
immunization schedules, HBV has remained a health problem in various stages such as …

New immunotherapeutic approaches for cancer treatment

A Kamrani, R Hosseinzadeh, N Shomali… - … -Research and Practice, 2023 - Elsevier
Neoplasms are a worldwide recognized non-contagious disease which has the most
mortality rate after cardiovascular diseases. For decades, there has been a vast amount of …

Angiogenesis in lung cancer: understanding the roles of growth factors

TYS Ngaha, AV Zhilenkova, FE Essogmo, IK Uchendu… - Cancers, 2023 - mdpi.com
Simple Summary Growth factors promote angiogenesis, which is a critical process in the
development of tumors. One of the therapeutic techniques being investigated in the …

Current advances in modulating tumor hypoxia for enhanced therapeutic efficacy

Z Liu, X Liu, W Zhang, R Gao, H Wei, CY Yu - Acta Biomaterialia, 2024 - Elsevier
Hypoxia is a common feature of most solid tumors, which promotes the proliferation,
invasion, metastasis, and therapeutic resistance of tumors. Researchers have been …

Anticancer activity of region B capsaicin analogs

KC Brown, KJ Modi, RS Light, AJ Cox… - Journal of Medicinal …, 2023 - ACS Publications
The heterocyclic vanilloid compound capsaicin is responsible for the spicy and pungent
flavor of chili peppers. Several convergent studies have shown that capsaicin suppresses …

Drug repurposing to enhance antitumor response to PD-1/PD-L1 immune checkpoint inhibitors

X Thuru, R Magnez, H El-Bouazzati, G Vergoten… - Cancers, 2022 - mdpi.com
Simple Summary Novel pharmacological approaches are needed to improve treatments of
advanced cancers, despite the considerable benefit of immunotherapy. New drugs are …