The role of the orbitofrontal cortex in alcohol use, abuse, and dependence

DE Moorman - Progress in Neuro-Psychopharmacology and …, 2018 - Elsevier
One of the major functions of the orbitofrontal cortex (OFC) is to promote flexible motivated
behavior. It is no surprise, therefore, that recent work has demonstrated a prominent impact …

Defining the place of habit in substance use disorders

Y Vandaele, PH Janak - Progress in Neuro-Psychopharmacology and …, 2018 - Elsevier
It has long been suggested that alcohol or substance use disorders could emerge from the
progressive development and dominance of drug habits. Like habits, drug-related behaviors …

[HTML][HTML] Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits

R Renteria, ET Baltz, CM Gremel - Nature communications, 2018 - nature.com
Addiction involves a predominance of habitual control mediated through action selection
processes in dorsal striatum. Research has largely focused on neural mechanisms …

[HTML][HTML] Chronic intermittent ethanol exposure enhances the excitability and synaptic plasticity of lateral orbitofrontal cortex neurons and induces a tolerance to the …

S Nimitvilai, MF Lopez, PJ Mulholland… - …, 2016 - nature.com
Alcoholism is associated with changes in brain reward and control systems, including the
prefrontal cortex. In prefrontal areas, the orbitofrontal cortex (OFC) has been suggested to …

[HTML][HTML] Diverging effects of adolescent ethanol exposure on tripartite synaptic development across prefrontal cortex subregions

CD Walker, HG Sexton, J Hyde, B Greene, ML Risher - Cells, 2022 - mdpi.com
Adolescence is a developmental period that encompasses, but is not limited to, puberty and
continues into early adulthood. During this period, maturation and refinement are observed …

Signals from the fourth dimension regulate drug relapse

PJ Mulholland, LJ Chandler, PW Kalivas - Trends in neurosciences, 2016 - cell.com
Despite the enormous societal burden of alcohol and drug addiction and abundant research
describing drug-induced maladaptive synaptic plasticity, there are few effective strategies for …

Glutamatergic plasticity and alcohol dependence-induced alterations in reward, affect and cognition

EJ Burnett, LJ Chandler… - Progress in Neuro …, 2016 - Elsevier
Introduction Alcohol dependence is characterized by a reduction in reward threshold,
development of a negative affective state, and significant cognitive impairments …

Chronic ethanol during adolescence impacts corticolimbic dendritic spines and behavior

NJ Jury, GA Pollack, MJ Ward, JL Bezek… - Alcoholism: clinical …, 2017 - Wiley Online Library
Background Risk for alcohol use disorders (AUD s) in adulthood is linked to alcohol drinking
during adolescence, but understanding of the neural and behavioral consequences of …

Orbitofrontal neuroadaptations and cross-species synaptic biomarkers in heavy-drinking macaques

S Nimitvilai, JD Uys, JJ Woodward… - Journal of …, 2017 - Soc Neuroscience
Cognitive impairments, uncontrolled drinking, and neuropathological cortical changes
characterize alcohol use disorder. Dysfunction of the orbitofrontal cortex (OFC), a critical …

Donepezil Reverses Dendritic Spine Morphology Adaptations and Fmr1 Epigenetic Modifications in Hippocampus of Adult Rats After Adolescent Alcohol Exposure

PJ Mulholland, TL Teppen, KM Miller… - Alcoholism: Clinical …, 2018 - Wiley Online Library
Background Adolescent intermittent ethanol (AIE) exposure produces persistent
impairments in cholinergic and epigenetic signaling and alters markers of synapses in the …