4-Thiazolidinone-bearing hybrid molecules in anticancer drug design
Oncological diseases have currently reached an epidemic scale, especially in industrialized
countries. Such a situation has prompted complex studies in medicinal chemistry focused on …
countries. Such a situation has prompted complex studies in medicinal chemistry focused on …
The bioactivity of thiazolidin-4-ones: A short review of the most recent studies
D Mech, A Kurowska, N Trotsko - International Journal of Molecular …, 2021 - mdpi.com
Thiazolidin-4-ones is an important heterocyclic ring system of a pharmacophore and a
privileged scaffold in medicinal chemistry. This review is focused on the latest scientific …
privileged scaffold in medicinal chemistry. This review is focused on the latest scientific …
Novel imidazo[2,1‐b]thiazole‐based anticancer agents as potential focal adhesion kinase inhibitors: Synthesis, in silico and in vitro evaluation
F Başoğlu, N Ulusoy‐Güzeldemirci… - Chemical Biology & …, 2021 - Wiley Online Library
The purpose of this study was to synthesize imidazo [2, 1‐b] thiazole derivatives,
characterize them with spectroscopical techniques and investigate for cytotoxic and …
characterize them with spectroscopical techniques and investigate for cytotoxic and …
Isolation, synthesis and bioactivity evaluation of isoquinoline alkaloids from Corydalis hendersonii Hemsl. against gastric cancer in vitro and in vivo
T Luo, Z Li, XM Deng, K Jiang, D Liu, HH Zhang… - Bioorganic & Medicinal …, 2022 - Elsevier
Isoquinoline alkaloid displays significant anti-gastric cancer effects due to its unique
structure, which is attracting more and more attention for the development of anti-gastric …
structure, which is attracting more and more attention for the development of anti-gastric …
[PDF][PDF] Hybrids of thiazolidin-4-ones and 1, 3, 4-thiadiazole: Synthesis and biological screening of a potential new class of acetylcholinesterae inhibitors
N Aggarwal, S Jain, N Chopra - Biointerface Res. Appl …, 2022 - biointerfaceresearch.com
Using propanoic acid and thiosemicarbazide as starting materials, a new sequence of
thiazolidin-4-one analogs with thiadiazole derivative was synthesized in appreciable yield …
thiazolidin-4-one analogs with thiadiazole derivative was synthesized in appreciable yield …
Synthesis of oxamide-hydrazone hybrid derivatives as potential anticancer agents
M Dehbid, R Tahmasvand, M Tasharofi… - Research in …, 2023 - journals.lww.com
Background and purpose: Considering various studies implying anticancer activity of the
hydrazone and oxamide derivatives through different mechanisms such as kinases and …
hydrazone and oxamide derivatives through different mechanisms such as kinases and …
Recent advancements in the development of anti-breast cancer synthetic small molecules
EB Elkaeed, HAAE Salam, A Sabt, GH Al-Ansary… - Molecules, 2021 - mdpi.com
Among all cancer types, breast cancer (BC) still stands as one of the most serious diseases
responsible for a large number of cancer-associated deaths among women worldwide, and …
responsible for a large number of cancer-associated deaths among women worldwide, and …
Synthetic strategies and medicinal perspectives of 4‐thiazolidinones: Recent developments and structure–activity relationship studies
PA Chawla, SK Wahan, M Negi… - Journal of …, 2023 - Wiley Online Library
The 4‐thiazolidinone moiety is a privileged scaffold showing diversity in biological
responses like antiinflammatory, antidiabetic, anticancer, antitubercular, anesthetic …
responses like antiinflammatory, antidiabetic, anticancer, antitubercular, anesthetic …
Recent literature on the synthesis of thiazole derivatives and their biological activities
TA Farghaly, GH Alfaifi… - Mini Reviews in Medicinal …, 2024 - ingentaconnect.com
The thiazole ring is naturally occurring and is primarily found in marine and microbial
sources. It has been identified in various compounds such as peptides, vitamins (thiamine) …
sources. It has been identified in various compounds such as peptides, vitamins (thiamine) …
Exploring the Potential of Substituted 4-Thiazolidinone Derivatives in the Treatment of Breast Cancer: Synthesis, Biological Screening and In Silico Studies
A series of 4-thiazolidinone conjugates bearing quinoline/indole/furan scaffolds were
designed as potential anti-breast cancer agents, synthesized, and investigated for their anti …
designed as potential anti-breast cancer agents, synthesized, and investigated for their anti …