Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

Aging is a biological phenomenon in which the structure and function of organisms declining
with the increasing of age. It has become a major risk factor of human diseases, including …

Ischemia-reperfusion (IR) injury is central to the pathology of major cardiovascular diseases,
such as stroke and myocardial infarction. IR injury is mediated by several factors including …

Sirtuins are class III histone deacetylases, whose enzymatic activity is dependent on NAD+
as a cofactor. Sirtuins are reported to modulate numerous activities by controlling gene …

The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …

Meteorin-like (METRNL) protein is a newly identified myokine that functions to modulate
energy expenditure and inflammation in adipose tissue. Herein, we aim to investigate the …

The antioxidant effects of resveratrol (3, 5, 4'‐trihydroxy‐trans‐stilbene) contribute
substantially to the health benefits of this compound. Resveratrol has been shown to be a …

Resveratrol, a natural polyphenolic compound, is found in various kinds of fruits, plants, and
their commercial products such as red wine. It has been demonstrated to exhibit a variety of …

Ageing is a plastic process and can be successfully modulated by some biomedical
approaches or pharmaceutics. In this manner it is possible to delay or even prevent some …