Malaria has been the pre-eminent cause of early mortality in many parts of the world
throughout much of the last five thousand years and, as a result, it is the strongest force for …

Plasmodium vivax is the main cause of malarial disease in Asia and South America.
Plasmodium vivax infection was thought to be absent in African populations who are Duffy …

Following unsuccessful eradication attempts there was a resurgence of malaria towards the
end of the 20th century. Renewed control efforts using a range of improved tools, such as …

The overwhelming dominance of Duffy blood group negativity among most people living in
sub-Saharan Africa has been considered the basis of their protection from endemic …

A better understanding of the occurrence and risk of Plasmodium vivax infection among
Duffy-negative individuals is required to guide further research on these infections across …

Background Asymptomatic falciparum and non-falciparum malaria infections are major
challenges to malaria control interventions, as they remain a source of continual infection in …

Duffy 抗原是红细胞膜表面抗原, 属于红细胞系统抗原. 抗原表达在Fy 糖蛋白的膜外环上. G
蛋白偶联受体, 是指G 蛋白的受体作用. 表达Duffy 抗原的Fy 糖蛋白就是一种G 蛋白 …

The discovery that Africans were resistant to infection by Plasmodium vivax (P. vivax) led to
the conclusion that P. vivax invasion relied on the P. vivax Duffy Binding Protein (PvDBP) …

The understanding that red blood cells (RBCs) lacking the Duffy receptor are resistant to
blood stage infection by Plasmodium vivax has provided the conceptual path for productive …

The absence of the Duffy protein at the surface of erythrocytes was considered for decades
to confer full protection against Plasmodium vivax as this blood group is the receptor for the …