Dysregulation in lipid metabolism is among the most prominent metabolic alterations in
cancer. Cancer cells harness lipid metabolism to obtain energy, components for biological …

Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy.
Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute …

Cellular lipid metabolism and homeostasis are controlled by sterol regulatory-element
binding proteins (SREBPs). In addition to performing canonical functions in the …

Non-alcoholic fatty liver disease (NAFLD) is a quickly emerging global health problem
representing the most common chronic liver disease in the world. Atherosclerotic …

Scap is a polytopic membrane protein that functions as a molecular machine to control the
cholesterol content of membranes in mammalian cells. In the 21 years since our laboratory …

One-fourth of all deaths in industrialized countries result from coronary heart disease. A
century of research has revealed the essential causative agent: cholesterol-carrying low …

The ability to sense and respond to fluctuations in environmental nutrient levels is a requisite
for life. Nutrient scarcity is a selective pressure that has shaped the evolution of most cellular …