Malaria elimination has recently been reinstated as a global health priority but current
therapies seem to be insufficient for the task. Elimination efforts require new drug classes …

The emergence of new viruses and resistant strains of pathogenic microorganisms has
become a powerful stimulus in the search for new drugs. Nucleosides are a promising class …

Mechanisms of action (MoAs) have been elusive for most antimalarial drugs in clinical use.
Decreasing responsiveness to antimalarial treatments stresses the need for a better …

New antimalarial targets are the prime need for the discovery of potent drug candidates. In
order to fulfill this objective, antimalarial drug researches are focusing on promising targets …

Enzymes achieve their transition states by dynamic conformational searches on the
femtosecond to picosecond time scale. Mimics of reactants at enzymatic transition states …

Transition state theory teaches that chemically stable mimics of enzymatic transition states
will bind tightly to their cognate enzymes. Kinetic isotope effects combined with …

Polygala boliviensis is found in the Brazilian semiarid region. This specie is little chemically
and biologically studied. Polygala spp. have different metabolites, especially coumarins …

The Immucillins are chemically stable analogues that mimic the ribocation and leaving-
group features of N-ribosyltransferase transition states. Infectious disease agents often rely …

Malaria continues to be a devastating burden on the world, causing the deaths of an
estimated 627000 people in 2012, with 482 000 of those being children under the age of 5 …

Malaria still affects around 200 million people and is responsible for more than 400,000
deaths per year, mostly children in subequatorial areas. This disease is caused by parasites …