Cell-penetrating peptides (CPPs) with sequences derived originally from a prion protein
(PrP) have been shown to exhibit both anti-prion and anti-amyloid properties particularly …

Over 4 decades of research support the link between Alzheimer disease (AD) and
somatostatin [somatotropin-releasing inhibitory factor (SRIF)]. SRIF and SRIF-expressing …

Oligomeric aggregates of the amyloid-beta peptide (1-42)(Aβ42) are regarded as a primary
cause of cytotoxicity related to membrane damage in Alzheimer's disease. However, a …

The neuroendocrine peptide somatostatin (SST) has long been thought of as influencing the
deposition of the amyloid β peptide (Aβ) in Alzheimer's disease (AD). Missing have been in …

Minerals in the Earth's crust have contributed to the natural functioning of ecosystems via
biogeochemical interactions. Linnaeite is a cobalt sulfide mineral with a cubic spinel …

Alzheimer's disease is associated with the formation of toxic aggregates of amyloid beta (Aβ)
peptides. Despite tremendous efforts, our understanding of the molecular mechanisms of …

S100B is an astrocytic extracellular Ca2+-binding protein implicated in Alzheimer's disease,
whose role as a holdase-type chaperone delaying Aβ42 aggregation and toxicity was …

The molecular underpinnings that govern the endoproteolytic release of the amyloid beta
peptide (Aβ) from the amyloid precursor protein (APP) are now quite well understood. The …

Correct folding of proteins is essential for maintaining a functional living cell. Misfolding and
aggregation of proteins, where non-native intermolecular interactions form large and highly …

Cell-penetrating peptides (CPPs) with sequences derived originally from a prion protein
(PrP) have been shown to exhibit both anti-prion and anti-amyloid properties particularly …