Recent developments in autism genetic research: A scientometric review from 2018 to 2022

M Lim, A Carollo, D Dimitriou, G Esposito - Genes, 2022 - mdpi.com
Genetic research in Autism Spectrum Disorder (ASD) has progressed tremendously in
recent decades. Dozens of genetic loci and hundreds of alterations in the genetic sequence …

Experimental models to study autism spectrum disorders: hiPSCs, rodents and zebrafish

A Pensado-López, S Veiga-Rúa, Á Carracedo… - Genes, 2020 - mdpi.com
Autism Spectrum Disorders (ASD) affect around 1.5% of the global population, which
manifest alterations in communication and socialization, as well as repetitive behaviors or …

Mitochondrial proteins encoded by the 22q11. 2 neurodevelopmental locus regulate neural stem and progenitor cell proliferation

PD Campbell, I Lee, S Thyme, M Granato - Molecular psychiatry, 2023 - nature.com
Microdeletion of a 3Mb region encompassing 45 protein-coding genes at chromosome
22q11. 2 (22q11. 2DS) predisposes individuals to multiple neurodevelopmental disorders …

New evidence for neurobehavioral toxicity of deltamethrin at environmentally relevant levels in zebrafish

L Lei, B Zhu, K Qiao, Y Zhou, X Chen, J Men… - Science of the Total …, 2022 - Elsevier
Deltamethrin, a widely used type II pyrethroid insecticide, was reported with neurotoxicity to
aquatic organisms, such as fish. However, the effects and potential mechanisms on the …

Top2a promotes the development of social behavior via PRC2 and H3K27me3

Y Geng, T Zhang, IG Alonzo, SC Godar, C Yates… - Science …, 2022 - science.org
Little is understood about the embryonic development of sociality. We screened 1120 known
drugs and found that embryonic inhibition of topoisomerase IIα (Top2a) resulted in lasting …

Peering into the mind: unraveling schizophrenia's secrets using models

JV Nani, AR Muotri, MAF Hayashi - Molecular Psychiatry, 2024 - nature.com
Schizophrenia (SCZ) is a complex mental disorder characterized by a range of symptoms,
including positive and negative symptoms, as well as cognitive impairments. Despite the …

Large-scale F0 CRISPR screens in vivo using MIC-Drop

S Parvez, ZJ Brandt, RT Peterson - Nature protocols, 2023 - nature.com
The zebrafish is a powerful model system for studying animal development, for modeling
genetic diseases, and for large-scale in vivo functional genetics. Because of its ease of use …

How can we obtain truly translational mouse models to improve clinical outcomes in schizophrenia?

SJ Clapcote - Disease Models & Mechanisms, 2022 - journals.biologists.com
Schizophrenia is a serious mental illness affecting 0.7% of the world's population. Despite
over 50 years of schizophrenia drug identification and development, there have been no …

The 3-hit animal models of schizophrenia: improving strategy to decipher and treat the disease?

S Percelay, C Lahogue, JM Billard, T Freret… - Neuroscience & …, 2024 - Elsevier
Schizophrenia is a complex disease related to combination and interactions between
genetic and environmental factors, with an epigenetic influence. After the development of the …

[HTML][HTML] Zebrafish as a model to investigate the CRH axis and interactions with DISC1

H Eachus, S Ryu, M Placzek, J Wood - Current Opinion in Endocrine and …, 2022 - Elsevier
Release of corticotropin-releasing hormone (CRH) from CRH neurons activates the
hypothalamo–pituitary–adrenal (HPA) axis, one of the main physiological stress response …