Recent developments in autism genetic research: A scientometric review from 2018 to 2022
Genetic research in Autism Spectrum Disorder (ASD) has progressed tremendously in
recent decades. Dozens of genetic loci and hundreds of alterations in the genetic sequence …
recent decades. Dozens of genetic loci and hundreds of alterations in the genetic sequence …
Experimental models to study autism spectrum disorders: hiPSCs, rodents and zebrafish
A Pensado-López, S Veiga-Rúa, Á Carracedo… - Genes, 2020 - mdpi.com
Autism Spectrum Disorders (ASD) affect around 1.5% of the global population, which
manifest alterations in communication and socialization, as well as repetitive behaviors or …
manifest alterations in communication and socialization, as well as repetitive behaviors or …
Mitochondrial proteins encoded by the 22q11. 2 neurodevelopmental locus regulate neural stem and progenitor cell proliferation
PD Campbell, I Lee, S Thyme, M Granato - Molecular psychiatry, 2023 - nature.com
Microdeletion of a 3Mb region encompassing 45 protein-coding genes at chromosome
22q11. 2 (22q11. 2DS) predisposes individuals to multiple neurodevelopmental disorders …
22q11. 2 (22q11. 2DS) predisposes individuals to multiple neurodevelopmental disorders …
New evidence for neurobehavioral toxicity of deltamethrin at environmentally relevant levels in zebrafish
L Lei, B Zhu, K Qiao, Y Zhou, X Chen, J Men… - Science of the Total …, 2022 - Elsevier
Deltamethrin, a widely used type II pyrethroid insecticide, was reported with neurotoxicity to
aquatic organisms, such as fish. However, the effects and potential mechanisms on the …
aquatic organisms, such as fish. However, the effects and potential mechanisms on the …
Top2a promotes the development of social behavior via PRC2 and H3K27me3
Y Geng, T Zhang, IG Alonzo, SC Godar, C Yates… - Science …, 2022 - science.org
Little is understood about the embryonic development of sociality. We screened 1120 known
drugs and found that embryonic inhibition of topoisomerase IIα (Top2a) resulted in lasting …
drugs and found that embryonic inhibition of topoisomerase IIα (Top2a) resulted in lasting …
Peering into the mind: unraveling schizophrenia's secrets using models
Schizophrenia (SCZ) is a complex mental disorder characterized by a range of symptoms,
including positive and negative symptoms, as well as cognitive impairments. Despite the …
including positive and negative symptoms, as well as cognitive impairments. Despite the …
Large-scale F0 CRISPR screens in vivo using MIC-Drop
S Parvez, ZJ Brandt, RT Peterson - Nature protocols, 2023 - nature.com
The zebrafish is a powerful model system for studying animal development, for modeling
genetic diseases, and for large-scale in vivo functional genetics. Because of its ease of use …
genetic diseases, and for large-scale in vivo functional genetics. Because of its ease of use …
How can we obtain truly translational mouse models to improve clinical outcomes in schizophrenia?
SJ Clapcote - Disease Models & Mechanisms, 2022 - journals.biologists.com
Schizophrenia is a serious mental illness affecting 0.7% of the world's population. Despite
over 50 years of schizophrenia drug identification and development, there have been no …
over 50 years of schizophrenia drug identification and development, there have been no …
The 3-hit animal models of schizophrenia: improving strategy to decipher and treat the disease?
Schizophrenia is a complex disease related to combination and interactions between
genetic and environmental factors, with an epigenetic influence. After the development of the …
genetic and environmental factors, with an epigenetic influence. After the development of the …
[HTML][HTML] Zebrafish as a model to investigate the CRH axis and interactions with DISC1
Release of corticotropin-releasing hormone (CRH) from CRH neurons activates the
hypothalamo–pituitary–adrenal (HPA) axis, one of the main physiological stress response …
hypothalamo–pituitary–adrenal (HPA) axis, one of the main physiological stress response …