Anatomical basis of tolerance and immunity to intestinal antigens

AMI Mowat - Nature Reviews Immunology, 2003 - nature.com
The intestinal immune system has to discriminate between harmful and beneficial antigens.
Although strong protective immunity is essential to prevent invasion by pathogens …

Mechanisms of action of probiotics: recent advances

SC Ng, AL Hart, MA Kamm, AJ Stagg… - Inflammatory bowel …, 2009 - academic.oup.com
The intestinal microbiota plays a fundamental role in maintaining immune homeostasis. In
controlled clinical trials probiotic bacteria have demonstrated a benefit in treating …

Characteristics of intestinal dendritic cells in inflammatory bowel diseases

AL Hart, HO Al-Hassi, RJ Rigby, SJ Bell, AV Emmanuel… - Gastroenterology, 2005 - Elsevier
Background & Aims: Dendritic cells (DCs) recognize and respond to microbial structures
using pattern recognition receptors, including Toll-like receptors (TLRs). In the intestine, DCs …

Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease

JL Benjamin, CRH Hedin, A Koutsoumpas, SC Ng… - Gut, 2011 - gut.bmj.com
Introduction The commensal intestinal microbiota drive the inflammation associated with
Crohn's disease. However, bacteria such as bifidobacteria and Faecalibacterium prausnitzii …

Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease

JO Lindsay, K Whelan, AJ Stagg, P Gobin, HO Al-Hassi… - Gut, 2006 - gut.bmj.com
Background and aims: The intestinal microbiota play a pivotal role in the inflammation
associated with Crohn's disease through their interaction with the mucosal immune system …

Modulation of human dendritic cell phenotype and function by probiotic bacteria

AL Hart, K Lammers, P Brigidi, B Vitali, F Rizzello… - Gut, 2004 - gut.bmj.com
Background:“Probiotic” bacteria are effective in treating some inflammatory bowel diseases.
However which bacteria confer benefit and mechanisms of action remain poorly defined …

Dendritic cells in intestinal homeostasis and disease

M Rescigno, A Di Sabatino - The Journal of clinical …, 2009 - Am Soc Clin Investig
DCs are specialized APCs that orchestrate innate and adaptive immune responses. The
intestinal mucosa contains numerous DCs, which induce either protective immunity to …

Th1/Th17 immune response is induced by mesenteric lymph node dendritic cells in Crohn's disease

A Sakuraba, T Sato, N Kamada, M Kitazume, A Sugita… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: Dendritic cells (DCs) possess the most potent ability to induce
acquired immunity. However, their involvement in the pathogenesis of Crohn's disease (CD) …

Dendritic cells in the human decidua

L Gardner, A Moffett - Biology of reproduction, 2003 - academic.oup.com
Dendritic cells (DCs) in the pregnant human uterine mucosa have been poorly
characterized, although they are likely to regulate immune responses to both placental …

Human immunodeficiency virus type 1 activates plasmacytoid dendritic cells and concomitantly induces the bystander maturation of myeloid dendritic cells

JF Fonteneau, M Larsson, AS Beignon… - Journal of …, 2004 - Am Soc Microbiol
In this study, we analyzed the phenotypic and physiological consequences of the interaction
of plasmacytoid dendritic cells (pDCs) with human immunodeficiency virus type 1 (HIV-1) …