Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells
to exhibit their remarkable self-organizing properties, and the resulting organoids reflect key …

Corneal wound healing is a complex process involving cell death, migration, proliferation,
differentiation, and extracellular matrix remodeling. Many similarities are observed in the …

Junctional epidermolysis bullosa (JEB) is a severe and often lethal genetic disease caused
by mutations in genes encoding the basement membrane component laminin-332 …

Wounds are of a variety of types and each category has its own distinctive healing
requirements. This realization has spurred the development of a myriad of wound dressings …

Purpose: Despite extensive knowledge gained over the last 3 decades regarding limbal
stem cell deficiency (LSCD), the disease is not clearly defined, and there is lack of …

Mesenchymal stem cells (MSCs) are the focus of intensive efforts worldwide directed not
only at elucidating their nature and unique properties but also developing cell-based …

Despite many reports of putative stem-cell-based treatments in genetic and degenerative
disorders or severe injuries, the number of proven stem cell therapies has remained small …

Corneal transplantation or keratoplasty has developed rapidly in the past 10 years.
Penetrating keratoplasty, a procedure consisting of full-thickness replacement of the cornea …

Patient‐derived cancer cells (PDCs) and patient‐derived xenografts (PDXs) are often used
as tumor models, but have many shortcomings. PDCs not only lack diversity in terms of cell …

To treat unilateral limbal stem cell (LSC) deficiency, we developed cultivated autologous
limbal epithelial cells (CALEC) using an innovative xenobiotic-free, serum-free, antibiotic …