Dissecting the clinical heterogeneity of early-onset Alzheimer's disease
Early-onset Alzheimer's disease (EOAD) is a rare but particularly devastating form of AD.
Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same …
Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same …
Tau and tauopathies
T Arendt, JT Stieler, M Holzer - Brain research bulletin, 2016 - Elsevier
Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …
APP, PSEN1, and PSEN2 mutations in early-onset Alzheimer disease: A genetic screening study of familial and sporadic cases
Background Amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2
(PSEN2) mutations cause autosomal dominant forms of early-onset Alzheimer disease (AD …
(PSEN2) mutations cause autosomal dominant forms of early-onset Alzheimer disease (AD …
Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture
Genetic association studies have identified 44 common genome-wide significant risk loci for
late-onset Alzheimer's disease (LOAD). However, LOAD genetic architecture and prediction …
late-onset Alzheimer's disease (LOAD). However, LOAD genetic architecture and prediction …
[HTML][HTML] Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: a review and synthesis
As the population ages due to demographic trends and gains in life expectancy, the
incidence and prevalence of dementia increases, and the need to understand the etiology …
incidence and prevalence of dementia increases, and the need to understand the etiology …
Positron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN)
Abstract The Dominantly Inherited Alzheimer Network (DIAN) is an international
collaboration studying autosomal dominant Alzheimer disease (ADAD). ADAD arises from …
collaboration studying autosomal dominant Alzheimer disease (ADAD). ADAD arises from …
Alzheimer's disease risk genes and mechanisms of disease pathogenesis
We review the genetic risk factors for late-onset Alzheimer's disease (AD) and their role in
AD pathogenesis. More recent advances in understanding of the human genome …
AD pathogenesis. More recent advances in understanding of the human genome …
A global view of the genetic basis of Alzheimer disease
C Reitz, MA Pericak-Vance, T Foroud… - Nature Reviews …, 2023 - nature.com
The risk of Alzheimer disease (AD) increases with age, family history and informative genetic
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …
variants. Sadly, there is still no cure or means of prevention. As in other complex diseases …
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
RJ Bateman, C Xiong, TLS Benzinger… - … England Journal of …, 2012 - Mass Medical Soc
Background The order and magnitude of pathologic processes in Alzheimer's disease are
not well understood, partly because the disease develops over many years. Autosomal …
not well understood, partly because the disease develops over many years. Autosomal …
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
The prevalence of dementia in the Western world in people over the age of 60 has been
estimated to be greater than 5%, about two-thirds of which are due to Alzheimer's disease …
estimated to be greater than 5%, about two-thirds of which are due to Alzheimer's disease …