Over half a century has passed since interferons (IFNs) were discovered and shown to
inhibit virus infection in cultured cells. Since then, researchers have steadily brought to light …

The year 2011 marks the centenary of Francis Peyton Rous's landmark experiments on an
avian cancer virus. Since then, seven human viruses have been found to cause 10–15% of …

Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic lung
disease with a poor prognosis. Although many factors have been identified that possibly …

Kaposi's sarcoma (KS) is the most common cancer in HIV-infected untreated individuals.
Kaposi's sarcoma-associated herpesvirus (KSHV; also known as human herpesvirus 8 …

The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was
identified in the late 1980s in the context of research into the type I interferon system …

▪ Abstract An expanding family of BCL-2 related proteins share homology, clustered within
four conserved regions, namely BCL-2 homology (BH1-4) domains, which control the ability …

Humans have a close phylogenetic relationship with nonhuman primates (NHPs) and share
many physiological parallels, such as highly similar immune systems, with them. Importantly …

The interferon regulatory factors (IRF) consist of a growing family of related transcription
proteins first identified as regulators of the alpha beta interferon (IFN-α/β) gene promoters …

In 1872, Moritz Kaposi, a Hungarian dermatologist, described five men with aggressive
“idiopathic multiple pigmented sarcomas of the skin.” 1 One patient died of gastrointestinal …

This paper is about the taxonomy and genomics of herpesviruses. Each theme is presented
as a digest of current information flanked by commentaries on past activities and future …