Emerging role of the spleen in the pharmacokinetics of monoclonal antibodies, nanoparticles and exosomes

M Cataldi, C Vigliotti, T Mosca, MR Cammarota… - International journal of …, 2017 - mdpi.com
After being absorbed, drugs distribute in the body in part to reach target tissues, in part to be
disposed in tissues where they do not exert clinically-relevant effects. Therapeutically …

Chemotherapy of leishmaniasis: present challenges

SRB Uliana, CT Trinconi, AC Coelho - Parasitology, 2018 - cambridge.org
Cutaneous and visceral leishmaniasis are amongst the most devastating infectious diseases
of our time, affecting millions of people worldwide. The treatment of these serious diseases …

Leishmania–macrophage interactions: Insights into the redox biology

T Van Assche, M Deschacht, RAI da Luz, L Maes… - Free Radical Biology …, 2011 - Elsevier
Leishmaniasis is a neglected tropical disease that affects about 350 million individuals
worldwide. The protozoan parasite has a relatively simple life cycle with two principal …

Drug resistance in visceral leishmaniasis

HC Maltezou - BioMed Research International, 2010 - Wiley Online Library
Visceral leishmaniasis remains a public health problem worldwide. This illness was
included by the World Health Organization in the list of neglected tropical diseases targeted …

Recent developments and future prospects in the treatment of visceral leishmaniasis

S Sundar, A Singh - Therapeutic advances in infectious …, 2016 - journals.sagepub.com
Limited therapeutic options in visceral leishmaniasis (VL) make the treatment of this
neglected disease very challenging. In addition to this, long treatment duration and toxic …

Molecular and immunological toxic effects of nanoparticles

RK Pandey, VK Prajapati - International journal of biological …, 2018 - Elsevier
Nanoparticles have emerged as a boon for the public health applications such as drug
delivery, diagnostic, and imaging. Biodegradable and non-bio degradable nanoparticles …

Nanotechnology and human health: risks and benefits

AG Cattaneo, R Gornati, E Sabbioni… - Journal of applied …, 2010 - Wiley Online Library
Nanotechnology is expected to be promising in many fields of medical applications, mainly
in cancer treatment. While a large number of very attractive exploitations open up for the …

Targeted killing of Leishmania donovani in vivo and in vitro with amphotericin B attached to functionalized carbon nanotubes

VK Prajapati, K Awasthi, S Gautam… - Journal of …, 2011 - academic.oup.com
Objectives This study describes the antileishmanial efficacy of the novel drug formulation of
amphotericin B (AmB) attached to functionalized carbon nanotubes (f-CNTs) and compares …

Cell delivery of therapeutic nanoparticles

JE McMillan, E Batrakova, HE Gendelman - Progress in molecular biology …, 2011 - Elsevier
Nanomedicine seeks to manufacture drugs and other biologically relevant molecules that
are packaged into nanoscale systems for improved delivery. This includes known drugs …

Oral particle uptake and organ targeting drives the activity of amphotericin B nanoparticles

DR Serrano, A Lalatsa, MA Dea-Ayuela… - Molecular …, 2015 - ACS Publications
There are very few drug delivery systems that target key organs via the oral route, as oral
delivery advances normally address gastrointestinal drug dissolution, permeation, and …