Iron is an essential trace element for the human body, and its deficiency or excess can
induce a variety of biological processes. Plenty of evidences have shown that iron …

Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian
tissues. It plays a very critical role in many pathophysiological processes in the body. It can …

Systemic iron homeostasis needs to be tightly controlled, as both deficiency and excess iron
cause major global health concerns, such as iron deficiency anemia, hemochromatosis, etc …

Oligodendrocyte progenitor cells (OPCs) differentiate to myelin-producing mature
oligodendrocytes and enwrap growing or demyelinated axons during development and post …

The clinical use of 5-fluorouracil (5-FU), a potent antitumor agent, was limited by severe
cardiotoxic effects. The present study was aimed to investigate the protective effects of …

Ethnopharmacological relevance Aconitum species, with a long history of traditional
application, were applied to treat rheumatism, arthritis, stroke, and pain in Chinese medical …

Ferroptosis is a recently recognized form of cell death with distinct features in terms of
morphology, biochemistry, and molecular mechanisms. Unlike other types of cell death …

Head and neck squamous cell carcinomas (HNSCCs) are a type of cancer originating in the
mucosal epithelium of the mouth, pharynx, and larynx, the sixth most common cancer in the …

Lipid metabolism disorders and mitochondrial dysfunction contribute to the progression of
diabetes and chronic liver disease (CLD). Ferroptosis, as a form of cell death centered on …

Ferroptosis is a form of regulated cell death resulting from iron accumulation and lipid
peroxidation. Iron dyshomeostasis and peroxidation damage of neurons in some particular …