The pulmonary epithelium serves as a barrier to prevent access of the inspired luminal
contents to the subepithelium. In addition, the epithelium dictates the initial responses of the …

Objective: Mechanical ventilation (MV) has long been used as a life-sustaining approach for
several decades. However, researchers realized that MV not only brings benefits to patients …

No targeted therapies exist to counteract Hyperoxia (HO)-induced Acute Lung Injury (HALI).
We previously found that HO downregulates alveolar K2P2. 1 (TREK-1) K+ channels, which …

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a devastating
respiratory disorder with high rates of mortality and morbidity, but the detailed underlying …

Acute respiratory distress syndrome (ARDS) is essentially a clinical syndrome of
noncardiogenic pulmonary edema and hypoxia that contributes to significant morbidity and …

Acute respiratory distress syndrome (ARDS) is characterized by an exacerbated
inflammatory response, severe damage to the alveolar-capillary barrier and a secondary …

We previously proposed a role for the two-pore domain potassium (K2P) channel TREK-1 in
hyperoxia (HO)-induced lung injury. To determine whether redundancy among the three …

We recently established a role for the stretch-activated two-pore-domain K+ (K2P) channel
TREK-1 (K2P2. 1) in inflammatory cytokine secretion using models of hyperoxia …

Mechanical ventilation (MV) and oxygen therapy (hyperoxia; HO) comprise the cornerstones
of life-saving interventions for patients with acute respiratory distress syndrome (ARDS) …

Epithelial barrier integrity is critical to maintain the homeostasis in the body. The regulatory
mechanism of the epithelial barrier function has not been fully understood. This study aims …