According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

Over the past several years, there has been a surge in blood biomarker studies examining
the value of plasma or serum neurofilament light (NfL) as a biomarker of neurodegeneration …

Alzheimer's disease (AD) is a progressive degenerative neurological illness with insidious
onset. Due to the complexity of the pathogenesis of AD and different pathological changes …

Background Blood-derived mitochondrial DNA copy number (mtDNA-CN) is a proxy
measurement of mitochondrial function in the peripheral and central systems. Abnormal …

Neurofilament light chains (NfL) are neuron-specific cytoskeletal proteins whose plasmatic
concentrations have been explored as a clinically useful marker in several types of …

Background Auraptene (AUR) and naringenin (NAR) are citrus-derived phytochemicals that
influence several biological mechanisms associated with cognitive decline, including …

Frontotemporal dementia (FTD) is one of the most common neurodegenerative diseases,
encompassing a myriad of different, clinically distinct subtypes which all target the …

Mild cognitive impairment (MCI) is often considered an early stage of dementia, with
estimated rates of progression to dementia up to 80–90% after approximately 6 years from …

Background and purpose We aimed to evaluate the accuracy of plasma neurofilament light
chain (NfL) in predicting Alzheimer's disease (AD) and the progression of cognitive decline …

Introduction and aim NfL and GFAP are promising blood-based biomarkers for Alzheimer's
disease. However, few studies have explored plasma GFAP in the prodromal and preclinical …