Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in
age-related neurodegenerative disorders, Alzheimer's disease, Parkinson's disease …

The use of zinc in medicinal skin cream was mentioned in Egyptian papyri from 2000 BC (for
example, the Smith Papyrus), and zinc has apparently been used fairly steadily throughout …

A hypothetical model of Alzheimer's disease (AD) as a uniquely human brain disorder
rooted in its exceptional process of myelination is presented. Cortical regions with the most …

There is a growing body of evidence to support a role for oxidative stress in Alzheimer's
disease (AD), with increased levels of lipid peroxidation, DNA and protein oxidation …

Disrupted energy metabolism, in particular reduced activity of cytochrome oxidase (EC 1.9.
3.1), α‐ketoglutarate dehydrogenase (EC 1.2. 4.2) and pyruvate dehydrogenase (EC 1.2 …

Although much maligned, the amyloid-β (Aβ) protein has been shown to possess a number
of trophic properties that emanate from the protein's ability to bind Cu, Fe and Zn. Aβ …

Metal ions are involved in Alzheimer's disease (AD) via their ability to induce aggregation of
amyloidogenic peptide and production of Reactive Oxygen Species (ROS), two key events …

Aggregation of the β‐amyloid peptide (Aβ) to amyloid plaques is a key event in Alzheimer's
disease. According to the amyloid‐cascade hypothesis, Aβ aggregates are toxic to neurons …

The formation of extracellular or intracellular deposits of amyloid-like protein fibrils is a
prominent pathological feature of many different neurodegenerative diseases, including …

Oxidative stress is considered as an important factor and an early event in the etiology of
Alzheimer's disease (AD). Cu bound to the peptide amyloid‐β (Aβ) is found in AD brains …