The Wnt/β-catenin signaling pathway plays important roles in embryonic development and
tissue homeostasis. Wnt signaling is induced, and β-catenin is activated, associated with the …

The extracellular matrix (ECM) is a biological substrate composed of collagens,
proteoglycans and glycoproteins that ensures proper cell migration and adhesion and keeps …

The pace of repair declines with age and, while exposure to a young circulation can
rejuvenate fracture repair, the cell types and factors responsible for rejuvenation are …

Interactions between vascular smooth muscle cells (VSMCs), endothelial cells (ECs),
pericytes (PCs) and macrophages (MФ), the major components of blood vessels, play a …

Failure to regenerate injured alveoli functionally and promptly causes a high incidence of
fatality in coronavirus disease 2019 (COVID-19). How elevated plasminogen activator …

The standard of care for obstructive atherosclerotic coronary disease is revascularization,
predominantly achieved via percutaneous placement of a stent with concurrent medical …

Myeloperoxidase (MPO)-derived hypochlorous (HOCl) reacts with membrane plasmalogens
to yield α-chlorofatty aldehydes such as 2-chlorofatty aldehyde (2-ClFALD) and its …

Background Impaired cutaneous wound healing is common in humans, and treatments are
often ineffective. Based on the significant emotional and economic burden of impaired …

The LDL family of receptors and its member low‐density lipoprotein receptor‐related protein
1 (LRP1) have classically been associated with a modulation of lipoprotein metabolism …

Cardiac fibrosis is one of the common pathological processes in many cardiovascular
diseases characterized by excessive extracellular matrix deposition. SerpinE2 is a kind of …