Macropinocytosis is defined as an actin-dependent but coat-and dynamin-independent
endocytic uptake process, which generates large intracellular vesicles (macropinosomes) …

Macropinocytosis is increasingly recognized for its versatile adaptations and functions as a
highly conserved, ubiquitous pathway for the bulk uptake of fluid, particulate cargo, and …

Highlights•IEC invasion is a crucial step in the life cycle of non-typhoidal Salmonella.•TTSS-
1 effectors SopE/E2 and particularly SipA mediate IEC invasion in mice.•Entry structures …

Within epithelial cells, Pseudomonas aeruginosa depends on its type III secretion system
(T3SS) to escape vacuoles and replicate rapidly in the cytosol. Previously, it was assumed …

Interferon-inducible guanylate-binding proteins (GBPs) promote cell-intrinsic defense
through host cell death. GBPs target pathogens and pathogen-containing vacuoles and …

Intracellular bacterial pathogens inject effector proteins to hijack host cellular processes and
promote their survival and proliferation. To systematically map effector-host protein-protein …

Salmonella utilizes a type 3 secretion system to translocate virulence proteins (effectors) into
host cells during infection. The effectors modulate host cell machinery to drive uptake of the …

Invasive bacteria colonise their host tissues by establishing niches inside eukaryotic cells,
where they grow either in the cytosol or inside a specialised vacuole. These two distinct …

Salmonella Typhimurium (S. Typhimurium) is an enteric bacterium capable of invading a
wide range of hosts, including rodents and humans. It targets different host cell types …

Intracellular bacterial pathogens gain entry to mammalian cells inside a vacuole derived
from the host membrane. Some of them escape the bacteria-containing vacuole (BCV) and …