Antifungals
S Campoy, JL Adrio - Biochemical pharmacology, 2017 - Elsevier
The need for new antifungal agents is undeniable. Current therapeutic choices for the
treatment of invasive fungal infections are limited to three classes of drugs. Most used …
treatment of invasive fungal infections are limited to three classes of drugs. Most used …
Lipid biosynthesis as an antifungal target
J Pan, C Hu, JH Yu - Journal of Fungi, 2018 - mdpi.com
Lipids, commonly including phospholipids, sphingolipids, fatty acids, sterols, and
triacylglycerols (TAGs), are important biomolecules for the viability of all cells …
triacylglycerols (TAGs), are important biomolecules for the viability of all cells …
Current challenges of research on filamentous fungi in relation to human welfare and a sustainable bio-economy: a white paper
V Meyer, MR Andersen, AA Brakhage… - Fungal biology and …, 2016 - Springer
The EUROFUNG network is a virtual centre of multidisciplinary expertise in the field of fungal
biotechnology. The first academic-industry Think Tank was hosted by EUROFUNG to …
biotechnology. The first academic-industry Think Tank was hosted by EUROFUNG to …
Post-translational modifications drive success and failure of fungal–host interactions
C Retanal, B Ball, J Geddes-McAlister - Journal of Fungi, 2021 - mdpi.com
Post-translational modifications (PTMs) change the structure and function of proteins and
regulate a diverse array of biological processes. Fungal pathogens rely on PTMs to …
regulate a diverse array of biological processes. Fungal pathogens rely on PTMs to …
Role of amino acid metabolism in the virulence of human pathogenic fungi
E Garbe, S Vylkova - Current Clinical Microbiology Reports, 2019 - Springer
Abstract Purpose of the Review The success of Candida albicans, Aspergillus fumigatus,
and Cryptococcus neoformans as fungal pathogens depends on their rapid adaptation to …
and Cryptococcus neoformans as fungal pathogens depends on their rapid adaptation to …
Riboflavin and pantothenic acid biosynthesis are crucial for iron homeostasis and virulence in the pathogenic mold Aspergillus fumigatus
Background: Aspergillus fumigatus is the most prevalent airborne fungal pathogen, causing
invasive fungal infections mainly in immunosuppressed individuals. Death rates from …
invasive fungal infections mainly in immunosuppressed individuals. Death rates from …
A Multifaceted Role of Tryptophan Metabolism and Indoleamine 2,3-Dioxygenase Activity in Aspergillus fumigatus–Host Interactions
Aspergillus fumigatus is the most prevalent filamentous fungal pathogen of humans, causing
either severe allergic bronchopulmonary aspergillosis or often fatal invasive pulmonary …
either severe allergic bronchopulmonary aspergillosis or often fatal invasive pulmonary …
The Essential Thioredoxin Reductase of the Human Pathogenic Mold Aspergillus fumigatus Is a Promising Antifungal Target
J Binder, Y Shadkchan, N Osherov… - Frontiers in …, 2020 - frontiersin.org
The identification of cellular targets for antifungal compounds is a cornerstone for the
development of novel antimycotics, for which a significant need exists due to increasing …
development of novel antimycotics, for which a significant need exists due to increasing …
The role of methionine synthases in fungal metabolism and virulence
J Scott, J Amich - Essays in Biochemistry, 2023 - portlandpress.com
Methionine synthases (MetH) catalyse the methylation of homocysteine (Hcy) with 5-methyl-
tetrahydrofolate (5, methyl-THF) acting as methyl donor, to form methionine (Met) and …
tetrahydrofolate (5, methyl-THF) acting as methyl donor, to form methionine (Met) and …
Exploring drug treatment patterns based on the action of drug and multilayer network model
Some drugs can be used to treat multiple diseases, suggesting potential patterns in drug
treatment. Determination of drug treatment patterns can improve our understanding of the …
treatment. Determination of drug treatment patterns can improve our understanding of the …