Mechanisms controlling transcription and its regulation are fundamental to our
understanding of molecular biology and, ultimately, cellular biology. Our knowledge of …

Work in the 1990s has substantially increased our understanding of supercoiling
conformations and energetics. We now know many of the basic properties of supercoiled …

Publisher Summary This chapter discusses the structure and function of DNA. DNA occupies
a critical role in cells, because it is the source of all intrinsic genetic information. Chemically …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

Previous studies have suggested that transcription elongation results in changes in
chromatin structure. Here we present studies of Saccharomyces cerevisiae Spt6, a …

The mechanism by which nucleosome cores are displaced and re-formed during
transcription in vitro has been investigated. A nucleosome core was assembled on a short …

Purpose: Antineoplastic drugs belonging to platinum or taxane families are severely
neurotoxic, inducing the onset of disabling peripheral neuropathies with different clinical …

Unique roles have been identified for the histone octamer in the formation and stabilization
of higher order chromatin structures. Histone octamers were assembled onto 12 tandem …

Chromatin remodeling can facilitate the recruitment of RNA polymerase II (Pol II) to targeted
promoters, as well as enhancing the level of transcription. Here, we describe a further key …

ABSTRACT A nucleosomal array consists of core histone octamer-DNA complexes spaced
at∼ 200 bp intervals along a DNA molecule. Nucleosomal arrays are the fundamental …