Adult stem cells that are tightly regulated by the specific microenvironment, or the stem cell
niche, function to maintain tissue homeostasis and regeneration after damage. This …

Mesenchymal stem/stromal cells (MSCs) are a reservoir for tissue homeostasis and repair
that age during organismal aging. Beside the fundamental in vivo role of MSCs, they have …

Senescence of bone marrow mesenchymal stem cells (BMSCs) impairs stemness and
osteogenic differentiation, but the key regulators for senescence and the related …

In vertebrates, bone is considered an osteoimmune system which encompasses functions of
a locomotive organ, a mineral reservoir, a hormonal organ, a stem cell pool and a cradle for …

Despite advances in biomedical research, fracture nonunion rates have remained stable
throughout the years. Long-bone fractures have a high likelihood of nonunion, but the …

Background Angiogenesis plays an important role in tissue repair and regeneration, and
conditioned medium (CM) derived from mesenchymal stem cells (MSC-CM) possesses pro …

Background Immunosuppressive properties grant mesenchymal stromal cells (MSCs)
promising potential for treating autoimmune diseases. As autologous MSCs suffer from …

Mesenchymal stem cells (MSCs) are stem cells with the potential ability to differentiate into
various cells and the ability to self-renew and resemble fibroblasts. These cells can adhere …

Healing of fractures and bone defects normally follows an orderly series of events including
formation of a hematoma and an initial stage of inflammation, development of soft callus …

Adipose-derived stromal cells (ASCs) are now recognized as an accessible, abundant, and
reliable stem cells for tissue engineering and regenerative medicine. However, ASCs should …