Coordinating cell growth with nutrient availability is critical for cell survival. The evolutionarily
conserved TOR (target of rapamycin) controls cell growth in response to nutrients, in …

The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to
coordinate cell growth, metabolism and autophagy. Extensive research has mapped the …

Nutrient sensing by cells is crucial, and when this sensing mechanism is disturbed, human
disease can occur. mTOR complex 1 (mTORC1) senses amino acids to control cell growth …

Tolerance to antifungal drug concentrations above the minimal inhibitory concentration
(MIC) is rarely quantified, and current clinical recommendations suggest it should be …

The AMP-activated protein kinase (AMPK) and the target of rapamycin complex 1 (TORC1)
are central kinase modules of two opposing signaling pathways that control eukaryotic cell …

Genome-metabolism interactions enable cell growth. To probe the extent of these
interactions and delineate their functional contributions, we quantified the Saccharomyces …

Yeast is a powerful model for systems genetics. We present a versatile, time-and labor-
efficient method to functionally explore the Saccharomyces cerevisiae genome using …

The eukaryotic TORC1 kinase is a homeostatic controller of growth that integrates nutritional
cues and mediates signals primarily from the surface of lysosomes or vacuoles. Amino acids …

Extensive work has characterized endoplasmic reticulum (ER) and mitochondrial stress
responses. In contrast, very little has been published about stress responses in lysosomes; …

In response to amino acid supply, mTORC1, a master regulator of cell growth, is recruited to
the lysosome and activated by the small GTPase Rheb. However, the intracellular …