NLRP3 Inflammasomes in Parkinson's disease and their Regulation by Parkin

YQ Yan, Y Fang, R Zheng, JL Pu, BR Zhang - Neuroscience, 2020 - Elsevier
Chronic inflammation might correlate with the formation of α-synuclein oligomers,
subsequently leading to dopaminergic (DA) neuronal death in Parkinson's disease (PD). As …

Parkinson's disease and melanoma: co-occurrence and mechanisms

A Bose, GA Petsko, D Eliezer - Journal of Parkinson's disease, 2018 - content.iospress.com
Parkinson's disease (PD) is a neurodegenerative disorder that is characterized by loss of
dopaminergic neurons in the substantia nigra pars compacta, depletion of dopamine in the …

Linking Parkinson's Disease and Melanoma: Interplay Between α‐Synuclein and Pmel17 Amyloid Formation

DN Dean, JC Lee - Movement Disorders, 2021 - Wiley Online Library
Parkinson's disease (PD) is a neurodegenerative disorder associated with the death of
dopaminergic neurons within the substantia nigra of the brain. Melanoma is a cancer of …

Knocking out alpha-synuclein in melanoma cells dysregulates cellular iron metabolism and suppresses tumor growth

S Shekoohi, S Rajasekaran, D Patel, S Yang, W Liu… - Scientific Reports, 2021 - nature.com
The protein alpha-synuclein (α-syn) is unusual because, depending on its conformation and
the type of cell in which it is expressed, it is pro-death or pro-survival, triggering …

Prognostic significance of SNCA and its methylation in bladder cancer

Z Wu, C Xia, C Zhang, D Yang, K Ma - BMC cancer, 2022 - Springer
Background The epidemiological investigation of different cancer types in the global
population has reported a decreased risk of bladder cancer (BLCA) in Parkinson's diseases …

Distinct molecular mechanisms contribute to the reduction of melanoma growth and tumor pain after systemic and local depletion of alpha‐Synuclein in mice

E Niederberger, M Möller, E Mungo, M Hass… - The FASEB …, 2023 - Wiley Online Library
Epidemiological studies show a coincidence between Parkinson's disease (PD) and
malignant melanoma. It has been suggested that this relationship is due, at least in part, to …

Toward the discovery and development of effective modulators of α-synuclein amyloid aggregation

V Oliveri - European Journal of Medicinal Chemistry, 2019 - Elsevier
A host of human diseases, including Parkinson's disease and Dementia with Lewy bodies,
are suspected to be directly linked to protein aggregation. Amyloid protein aggregates and …

Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization

A Dominguez-Meijide, E Vasili, A König… - Scientific reports, 2020 - nature.com
Parkinson's disease (PD) and Alzheimer's disease (AD) are common neurodegenerative
disorders of the elderly and, therefore, affect a growing number of patients worldwide. Both …

Knocking out alpha-synuclein in melanoma cells downregulates L1CAM and decreases motility

N Gajendran, S Rajasekaran, SN Witt - Scientific Reports, 2023 - nature.com
The Parkinson's disease (PD) associated protein, alpha-synuclein (α-syn/SNCA), is highly
expressed in aggressive melanomas. The goal of this study was to reveal possible …

Cancer and parkinson's disease: Common targets, emerging hopes

PS Filippou, TF Outeiro - Movement Disorders, 2021 - Wiley Online Library
Cancer and neurodegeneration are two major leading causes of morbidity and death
worldwide. At first sight, the two fields do not seem to share much in common and, if …