Placebo and Nocebo Effects Placebo and nocebo effects (effects of patients' positive and
negative expectations) are powerful and pervasive in clinical practice. Neurobiologic …

Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …

Brain-wide association studies (BWAS)—which correlate individual differences in
phenotypic traits with measures of brain structure and function—have become a dominant …

Increasing evidence suggests that mental health and physical health are linked by neural
systems that jointly regulate somatic physiology and high-level cognition. Key systems …

Despite their ubiquitous presence, placebos and placebo effects retain an ambiguous and
unsettling presence in biomedicine. Specifically focused on chronic pain, this review …

The sensory, associative and limbic neocortical structures play a critical role in shaping
incoming noxious inputs to generate variable pain perceptions. Technological advances in …

The brain systems underlying placebo analgesia are insufficiently understood. Here we
performed a systematic, participant-level meta-analysis of experimental functional …

Pharmacological strategies for pain management have primarily focused on dampening
ascending neurotransmission and on opioid receptor–mediated therapies. Little is known …

Acute pain is a physiological response that causes an unpleasant sensory and emotional
experience in the presence of actual or potential tissue injury. Anatomically and …

Pain is a subjective sensory experience that can, mostly, be reported but cannot be directly
measured or quantified. Nevertheless, a suite of biomarkers related to mechanisms, neural …