Benzophenone: A ubiquitous scaffold in medicinal chemistry
K Surana, B Chaudhary, M Diwaker, S Sharma - MedChemComm, 2018 - pubs.rsc.org
The benzophenone scaffold represents a ubiquitous structure in medicinal chemistry
because it is found in several naturally occurring molecules which exhibit a variety of …
because it is found in several naturally occurring molecules which exhibit a variety of …
Discovery of 1-(5-bromopyrazin-2-yl)-1-[3-(trifluoromethyl) benzyl] urea as a promising anticancer drug via synthesis, characterization, biological screening, and …
Cancer and different types of tumors are still the most resistant diseases to available
therapeutic agents. Finding a highly effective anticancer drug is the first target and concern …
therapeutic agents. Finding a highly effective anticancer drug is the first target and concern …
[HTML][HTML] Synthesis of coumarin analogs appended with quinoline and thiazole moiety and their apoptogenic role against murine ascitic carcinoma
The synthesis and antiproliferative effect of a series of quinoline and thiazole containing
coumarin analogs 12a-d and 13a-f respectively, on mice leukemic cells was performed. The …
coumarin analogs 12a-d and 13a-f respectively, on mice leukemic cells was performed. The …
Design, synthesis and mechanistic studies of benzophenones hydrazone derivatives as cathepsin inhibitors
IA Abdel-Azziz, NH Amin, MT El-Saadi… - Journal of Molecular …, 2023 - Elsevier
A novel series of benzophenone hydrazone derivatives were synthesized and evaluated for
their antiproliferative activity. The thiosemicarbazone derivative 5c and guanylhydrazone …
their antiproliferative activity. The thiosemicarbazone derivative 5c and guanylhydrazone …
Design, synthesis, and anticancer evaluation of benzophenone derivatives bearing naphthalene moiety as novel tubulin polymerization inhibitors
G Wang, W Liu, J Tang, X Ma, Z Gong, Y Huang, Y Li… - Bioorganic …, 2020 - Elsevier
A series of benzophenone derivatives bearing naphthalene moiety were designed,
synthesized, characterized by 1 H NMR, 13 C NMR, and HRMS and evaluated for their …
synthesized, characterized by 1 H NMR, 13 C NMR, and HRMS and evaluated for their …
Quinoline-and Isoindoline-Integrated Polycyclic Compounds as Antioxidant, and Antidiabetic Agents Targeting the Dual Inhibition of α-Glycosidase and α-Amylase …
M Al-Ghorbani, O Alharbi, AB Al-Odayni, NAY Abduh - Pharmaceuticals, 2023 - mdpi.com
Novel analogs of quinoline and isoindoline containing various heterocycles, such as
tetrazole, triazole, pyrazole, and pyridine, were synthesized and characterized using FT-IR …
tetrazole, triazole, pyrazole, and pyridine, were synthesized and characterized using FT-IR …
Synthesis, analgesic, anti-inflammatory, COX/5-LOX inhibition, ulcerogenic evaluation, and docking study of benzimidazole bearing indole and benzophenone …
KMJ Nagesh, T Prashanth, HA Khamees… - Journal of Molecular …, 2022 - Elsevier
Inflammation therapy is particularly focused on the development of safer non-steroidal anti-
inflammatory drugs (NSAIDs), administered to control inflammation. It is typically considered …
inflammatory drugs (NSAIDs), administered to control inflammation. It is typically considered …
The Novel 4-Phenyl-2-Phenoxyacetamide Thiazoles modulates the tumor hypoxia leading to the crackdown of neoangiogenesis and evoking the cell death
Tumor microenvironment is a complex multistep event which involves several hallmarks that
transform the normal cell into cancerous cell. Designing the novel antagonistic molecule to …
transform the normal cell into cancerous cell. Designing the novel antagonistic molecule to …
Design, Synthesis, Characterization, and Analysis of Antimicrobial Property of Novel Benzophenone Fused Azetidinone Derivatives through In Vitro and In Silico …
LR Venkataravanappa, M Jyothi, HA Khamees… - Current Issues in …, 2022 - mdpi.com
A sequence of novel 2-(4-benzoyl-2-methyl-phenoxy)-N-(3-chloro-2-oxo-4-phenyl-azetidin-1-
yl)-acetamide analogues 9 (a–n) were synthesized by multistep synthesis. The newly …
yl)-acetamide analogues 9 (a–n) were synthesized by multistep synthesis. The newly …
Triazole derivatives of guttiferone-A inhibit the proliferation of HepG2 cells by modulating MAPK/ERK signaling and expression profiles of regulators of G1/S transition
DA Rodrigues, BL de Sousa, CG Pressete… - New Journal of …, 2023 - pubs.rsc.org
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths
worldwide. The mortality rate has not reduced despite introducing new therapeutic …
worldwide. The mortality rate has not reduced despite introducing new therapeutic …