Stem cells are characterized by their ability to self-renew and differentiate into many different
cell types. Research has focused primarily on how these processes are regulated at a …

Metastasis is initiated and sustained through therapy by cancer cells with stem-like and
immune-evasive properties, termed metastasis-initiating cells (MIC). Recent progress …

Abstract Around 30–40% of patients with colorectal cancer (CRC) undergoing curative
resection of the primary tumour will develop metastases in the subsequent years. Therapies …

Colorectal cancer (CRC) patient-derived organoids predict responses to chemotherapy.
Here we used them to investigate relapse after treatment. Patient-derived organoids expand …

Patient-derived organoids (PDOs) recapitulate tumor architecture, contain cancer stem cells
and have predictive value supporting personalized medicine. Here we describe a large …

Intestinal homeostasis is underpinned by LGR5+ve crypt-base columnar stem cells (CBCs),
but following injury, dedifferentiation results in the emergence of LGR5− ve regenerative …

Cancer cells are regulated by oncogenic mutations and microenvironmental signals, yet
these processes are often studied separately. To functionally map how cell-intrinsic and cell …

Single-cell RNA sequencing studies have suggested that total mRNA content correlates with
tumor phenotypes. Technical and analytical challenges, however, have so far impeded at …

Patient-derived organoids (PDOs) can model personalized therapy responses; however,
current screening technologies cannot reveal drug response mechanisms or how tumor …

Mesenchymal colorectal cancer (mCRC) is microsatellite stable (MSS), highly desmoplastic,
with CD8+ T cells excluded to the stromal periphery, resistant to immunotherapy, and driven …