Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …

Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to
migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune …

Chemokines and cytokines are critical for initiating and coordinating the organized and
sequential recruitment and activation of cells into Mycobacterium tuberculosis-infected …

Abstract The interleukin 12 (IL-12) family is unique in having the only heterodimeric
cytokines, including IL-12, IL-23, IL-27 and IL-35. This feature endows these cytokines with a …

There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

The adaptive immune response mediated by T cells is critical for control of Mycobacterium
tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens …

Immune responses to Mycobacterium tuberculosis are only partially effective; they drive the
bacteria into a latent state, but rarely eliminate them. Unfortunately, the latent state of M …

Dendritic cells (DCs) orchestrate a repertoire of immune responses that bring about
resistance to infection and silencing or tolerance to self. In the settings of infection and …

Aluminum-based adjuvants (aluminum salts or alum) are widely used in human vaccination,
although their mechanisms of action are poorly understood. Here we report that, in mice …