The role of oxidative stress in hyperuricemia and xanthine oxidoreductase (XOR) inhibitors
N Liu, H Xu, Q Sun, X Yu, W Chen… - Oxidative Medicine …, 2021 - Wiley Online Library
Uric acid is the end product of purine metabolism in humans. Hyperuricemia is a metabolic
disease caused by the increased formation or reduced excretion of serum uric acid (SUA) …
disease caused by the increased formation or reduced excretion of serum uric acid (SUA) …
[HTML][HTML] Adenosine receptors and brain diseases: neuroprotection and neurodegeneration
Adenosine acts in parallel as a neuromodulator and as a homeostatic modulator in the
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …
central nervous system. Its neuromodulatory role relies on a balanced activation of inhibitory …
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for …
Yatham LN, Kennedy SH, Parikh SV, Schaffer A, Beaulieu S, Alda M, O'Donovan C,
MacQueen G, McIntyre RS, Sharma V, Ravindran A, Young LT, Milev R, Bond DJ, Frey BN …
MacQueen G, McIntyre RS, Sharma V, Ravindran A, Young LT, Milev R, Bond DJ, Frey BN …
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) collaborative update of CANMAT guidelines for …
The Canadian Network for Mood and Anxiety Treatments (CANMAT) published guidelines
for the management of bipolar disorder in 2005, with a 2007 update. This second update, in …
for the management of bipolar disorder in 2005, with a 2007 update. This second update, in …
The role of adenosine receptors in mood and anxiety disorders
D van Calker, K Biber, K Domschke… - Journal of …, 2019 - Wiley Online Library
Adenosine receptor subtypes, first described 40 years ago, are known to regulate diverse
biological functions and have a role in various conditions, such as cerebral and cardiac …
biological functions and have a role in various conditions, such as cerebral and cardiac …
Shared metabolic and immune-inflammatory, oxidative and nitrosative stress pathways in the metabolic syndrome and mood disorders
LGP de Melo, SOV Nunes, G Anderson… - Progress in Neuro …, 2017 - Elsevier
This review examines the shared immune-inflammatory, oxidative and nitrosative stress
(IO&NS) and metabolic pathways underpinning metabolic syndrome (MetS), bipolar disorder …
(IO&NS) and metabolic pathways underpinning metabolic syndrome (MetS), bipolar disorder …
Evidence and gap map of studies assessing the effectiveness of interventions for people with disabilities in low‐and middle‐income countries
Background There are approximately 1 billion people in the world with some form of
disability. This corresponds to approximately 15% of the world's population (World Report on …
disability. This corresponds to approximately 15% of the world's population (World Report on …
Purinergic system dysfunction in mood disorders: a key target for developing improved therapeutics
Uric acid and purines (such as adenosine) regulate mood, sleep, activity, appetite, cognition,
memory, convulsive threshold, social interaction, drive, and impulsivity. A link between …
memory, convulsive threshold, social interaction, drive, and impulsivity. A link between …
Proposal of a guanine-based purinergic system in the mammalian central nervous system
Guanine-based purines have been traditionally studied as modulators of intracellular
processes, mainly G-protein activity. However, they also exert several extracellular effects …
processes, mainly G-protein activity. However, they also exert several extracellular effects …
A double-blind, randomized, placebo-controlled 4-week study on the efficacy and safety of the purinergic agents allopurinol and dipyridamole adjunctive to lithium in …
R Machado-Vieira, JC Soares, DR Lara… - Journal of Clinical …, 2008 - psychiatrist.com
Objective: The therapeutics for bipolar disorders are still far from adequate, and new options
with improved effectiveness, safety, and tolerability in a wide range of patients are …
with improved effectiveness, safety, and tolerability in a wide range of patients are …