Asthma and eczema (atopic dermatitis) are the most common chronic diseases of childhood.
These diseases are characterized by the production of high levels of immunoglobulin E in …

A genetic contribution to develop chronic obstructive pulmonary disease (COPD) is well
established. However, the specific genes responsible for enhanced risk or host differences …

Tobacco use is a leading contributor to disability and death worldwide, and genetic factors
contribute in part to the development of nicotine dependence. To identify novel genes for …

BACKGROUND: Although chronic obstructive pulmonary disease (COPD) has been
considered a disease of Caucasian men, recent data show mortality rising faster among …

Inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease
(COPD) exhibit stereotyped traits that are variably expressed in each person. In …

CLCA1 is a member of the CLCA (calcium-activated chloride channel regulator) family and
plays an essential role in goblet cell mucus production from the respiratory tract epithelium …

Rationale We aimed to identify differentially methylated regions (DMRs) in cord blood DNA
associated with childhood lung function, asthma and chronic obstructive pulmonary disease …

The chloride channel calcium-activated (CLCA) family are secreted proteins that regulate
both chloride transport and mucin expression, thus controlling the production of mucus in …

Cell-based therapies have shown promise for treating myriad chronic pulmonary diseases
through direct application of epithelial progenitors or by way of engineered tissue grafts or …

Study objectives: Interleukin (IL)-4, IL-13, and β 2-adrenoceptor (ADRB2) are involved in
airway hyperresponsiveness (AHR), and their coding genes are located on chromosome …