Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) belong to a superfamily of
nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize …

Protein S‐palmitoylation (hereinafter referred to as protein palmitoylation) is a reversible
lipid posttranslational modification catalyzed by the zinc finger DHHC‐type containing …

Upon binding their cognate receptors, ERα (ESR1) and ERβ (ESR2), estrogens activate
intracellular signaling cascades that have important consequences for cellular behavior …

Nutrition exerts a life-long impact on human health, and the interaction between nutrition
and health has been known for centuries. The recent literature has suggested that nutrition …

Protein S-palmitoylation is a reversible posttranslational modification of proteins with fatty
acids, an enzymatic process driven by a recently discovered family of protein …

The role of oestrogen in oncogenesis has been examined extensively, especially in the
context of breast cancer, and receptor modulators are an integral part of targeted treatment …

Estrogen is a kind of steroid compound that has extensive biologic activities. The effect of
estrogen is pleiotropic, affecting multiple systems in the body. There is accumulating …

Triple Negative breast cancer (TNBC) is a subtype of breast cancer that lacks the expression
of estrogen receptor (ER), progesterone receptor, and human epidermal growth factor …

Colorectal cancer (CRC) is a common gastrointestinal malignancy with higher incidence
and mortality rates in men compared to women, potentially due to the effects of estrogen …

Gastric signet ring cell carcinoma (GSRC) is a special subtype of gastric cancer (GC)
associated with poor prognosis, but an in-depth and systematic study of GSRC is lacking …