Mechanism of deep brain stimulation: inhibition, excitation, or disruption?

S Chiken, A Nambu - The neuroscientist, 2016 - journals.sagepub.com
Deep brain stimulation (DBS), applying high-frequency electrical stimulation to deep brain
structures, has now provided an effective therapeutic option for treatment of various …

The mechanisms of action of deep brain stimulation and ideas for the future development

K Udupa, R Chen - Progress in neurobiology, 2015 - Elsevier
Deep brain stimulation (DBS) has been used as a treatment of movement disorders such as
Parkinson's disease, dystonia, and essential tremor for over twenty years, and is a promising …

A large-scale model of the functioning brain

C Eliasmith, TC Stewart, X Choo, T Bekolay, T DeWolf… - science, 2012 - science.org
A central challenge for cognitive and systems neuroscience is to relate the incredibly
complex behavior of animals to the equally complex activity of their brains. Recently …

Subthalamic nucleus deep brain stimulation in primary cervical dystonia

JL Ostrem, CA Racine, GA Glass, JK Grace, MM Volz… - Neurology, 2011 - AAN Enterprises
Objectives: The globus pallidus internus (GPi) has been the primary target for deep brain
stimulation (DBS) to treat severe medication-refractory dystonia. Some patients with primary …

The external globus pallidus: progress and perspectives

DJ Hegeman, ES Hong… - European Journal of …, 2016 - Wiley Online Library
The external globus pallidus (GP e) of the basal ganglia is in a unique and powerful position
to influence processing of motor information by virtue of its widespread projections to all …

[HTML][HTML] Deep brain stimulation for movement disorders of basal ganglia origin: restoring function or functionality?

T Wichmann, MR DeLong - Neurotherapeutics, 2016 - Elsevier
Deep brain stimulation (DBS) is highly effective for both hypo-and hyperkinetic movement
disorders of basal ganglia origin. The clinical use of DBS is, in part, empiric, based on the …

The Canadian multicentre study of deep brain stimulation for cervical dystonia

ZHT Kiss, K Doig-Beyaert, M Eliasziw, J Tsui… - Brain, 2007 - academic.oup.com
Deep brain stimulation (DBS) of the globus pallidus pars interna (GPi) is an effective
treatment for generalized dystonia. Its role in the management of other types of dystonia is …

Treatment of dystonia with deep brain stimulation

JL Ostrem, PA Starr - Neurotherapeutics, 2008 - Springer
Pallidal deep brain stimulation (DBS) is an established treatment option for medically
refractive dystonia. The mechanism by which globus pallidus pars interna (GPi) DBS …

Latest view on the mechanism of action of deep brain stimulation

C Hammond, R Ammari, B Bioulac… - … : official journal of the …, 2008 - Wiley Online Library
How does deep brain stimulation (DBS) applied at high frequency (100 Hz and above, HFS)
in diverse points of cortico‐basal ganglia thalamo‐cortical loops alleviate symptoms of …

Pathological basal ganglia activity in movement disorders

T Wichmann, JO Dostrovsky - Neuroscience, 2011 - Elsevier
Our understanding of the pathophysiology of movement disorders and associated changes
in basal ganglia activities has significantly changed during the last few decades. This …