Cardiac metabolism is vital for heart function. Given that cardiac contraction requires a
continuous supply of ATP in large quantities, the role of fuel metabolism in the heart has …

Pulmonary hypertension is a progressive and often fatal cardiopulmonary condition
characterised by increased pulmonary arterial pressure, structural changes in the pulmonary …

Heart failure (HF) is still the leading cause of death worldwide, occurring with a variety of
complex mechanisms. However, most intervention for HF do not directly target the …

Cardiac fibrosis is characterized by the excessive deposition of extracellular matrix in the
myocardium with cardiac fibroblast activation, leading to chronic cardiac remodeling and …

Background Sarcopenia is an important factor in the postoperative outcome of
gastrointestinal cancer patients. However, little research has been carried out on potential …

BACKGROUND: Metabolic remodeling and mitochondrial dysfunction are hallmarks of heart
failure with reduced ejection fraction. However, their role in the pathogenesis of HF with …

Cardiovascular diseases are the main killers threatening human health. Many studies have
shown that abnormal energy metabolism plays a key role in the occurrence and …

Previous studies suggest that sex differences in lipid metabolism exist with females
demonstrating a higher utilization of lipids during exercise, which is mediated partly by …

For years, females were thought of as smaller men with complex hormonal cycles; as a
result, females have been largely excluded from preclinical and clinical research. However …

Background Mice with cardiomyocyte‐specific deletion of Bmal1, a core clock gene, had
spontaneous abnormal cardiac metabolism, dilated cardiomyopathy, and shortened …