Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is
best known for mediating axon repulsion in the developing nervous system. However, in …

Axon outgrowth and guidance to the proper target requires the coordination of filamentous
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …

Recent studies indicate the actin and microtubule cytoskeletons are a final common target of
many signaling cascades that influence the developing neuron. Regulation of polymer …

The Slit family is a family of secreted proteins that play important roles in various physiologic
and pathologic activities via interacting with Robo receptors. Slit/Robo signaling was first …

Slits mediate multiple axon guidance decisions, but the mechanisms underlying the
responses of growth cones to these cues remain poorly defined. We show here that collapse …

Several families of extracellular guidance cues have been implicated in guiding neurons
and axons to their appropriate destinations in the nervous system. Their receptors include …

The Abl-family non-receptor tyrosine kinases are essential regulators of the cytoskeleton.
They transduce diverse extracellular cues into cytoskeletal rearrangements that have …

The F-actin cytoskeleton is a fundamental component of all eukaryotic cells. It provides force
and stability and plays an integral role in a diverse array of cellular processes. The …

Cyclase-associated proteins (CAPs) are highly conserved actin monomer binding proteins
present in all eukaryotes. However, the mechanism by which CAPs contribute to actin …

Background: Dynamic remodeling of the actin cytoskeleton requires rapid turnover of actin
filaments, which is regulated in part by the actin filament severing/depolymerization factor …