Transient receptor potential (TRP) channels are recently identified proteins that form a
versatile family of ion channels, the majority of which are calcium permeable and exhibit …

Mechanosensitive ion channels comprise a broad group of proteins that sense mechanical
extracellular and intracellular changes, translating them into cation influx to adapt and …

The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously
expressed ion channel with intrinsic kinase activity. Molecular and electrophysiological …

Abstract Transient Receptor Potential (TRP) channel proteins are a diverse family of proteins
that are expressed in many organisms, tissues and cell types. TRP channels respond to a …

Neuroblastoma (NB) is the most common extracranial solid tumor often diagnosed in
childhood. Despite intense efforts to develop a successful treatment, current available …

Cancer is the second leading cause of death worldwide and accounted for an estimated 9.6
million deaths, or 1 in 6 deaths, in 2018. Despite recent advances in cancer prevention …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a very poor
prognosis. There is an urgent need to better understand the molecular mechanisms that …

Multiple sclerosis (MS) is a chronic inflammatory disorder of the central nervous system
(CNS), characterized by inflammation‐mediated demyelination, axonal injury and …

The exact mechanisms of Head and neck squamous carcinoma (HNSCC) chemoresistance
and metastatic transformation remain unclear. In recent decades, members of the transient …

Tumors are composed by a heterogeneous population of cells. Among them, a sub-
population of cells, termed cancer stem cells, exhibit stemness features, such as self …