Cancer is a disease of aging and, as the world's population ages, the number of older
persons with cancer is increasing and will make up a growing share of the oncology …

Clinical trials are a fundamental tool used to evaluate the efficacy and safety of new drugs
and medical devices and other health system interventions. The traditional clinical trials …

PURPOSE The aim of this joint guideline is to provide evidence-based recommendations to
practicing physicians and other health care providers on integrative approaches to …

Abstract Background Trastuzumab deruxtecan (T-DXd) has shown durable antitumor activity
in pretreated patients with HER2-positive advanced breast cancer (ABC), but its efficacy has …

A concerted commitment across research stakeholders is necessary to increase equity,
diversity, and inclusion (EDI) and address barriers to cancer clinical trial recruitment and …

There is a growing focus on making clinical trials more inclusive but the design of trial
eligibility criteria remains challenging,–. Here we systematically evaluate the effect of …

The Magic of Randomization Nonrandomized observational analyses have been promoted
as alternatives to randomized clinical trials. However, randomization ensures balance …

Background Barriers to cancer clinical trial participation have been the subject of frequent
study, but the rate of trial participation has not changed substantially over time. Studies often …

Background Patient participation in clinical trials is vital for knowledge advancement and
outcomes improvement. Few adult cancer patients participate in trials. Although patient …

Therapeutic advances for glioblastoma have been minimal over the past 2 decades. In light
of the multitude of recent phase III trials that have failed to meet their primary endpoints …