The BAFF-receptor (BAFFR) is encoded by the TNFRSF13C gene and is one of the main pro-
survival receptors in B cells. Its function is impressively documented in humans by a …

BAFF, a member of the TNF family, is a fundamental survival factor for transitional and
mature B cells. BAFF overexpression leads to an expanded B cell compartment and …

We have discovered a distinct mature B-cell subset that accumulates with age, which we
have termed age-associated B cells. These cells comprise up to 30% of mature B cells by 22 …

The role of BAFF in B cell self tolerance was examined by tracking the fate of anti-HEL self-
reactive B cells in BAFF transgenic mice using four different models of self-reactive B cell …

Identification of growth factors in neoplasias may be a target for future therapies by blocking
either growth factor receptor interaction or the induced pathway. Using gene expression …

Recent evidence indicates that B cells are instructed continuously by B-cell receptor (BCR)
signals to make crucial cell-fate decisions at several checkpoints during their development …

During their lifetime, cells encounter many life or death situations that challenge their very
own existence. Their survival depends on the interplay within a complex yet precisely …

BAFF, APRIL and their receptors play important immunological roles, especially in the B cell
arm of the immune system. A number of splice isoforms have been described for both …

Impaired humoral responses, as well as an increased propensity for autoimmunity, play an
important role in the development of immune system dysfunction associated with aging …

Peripheral autoantigen binding B cells are poorly competitive with naive B cells for survival
and undergo rapid cell death. However, in monoclonal Ig-transgenic mice lacking competitor …