After more than a century from its discovery, valproic acid (VPA) still represents one of the
most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a …

In the last years, a growing body of literature indicates an association between valproic acid
therapy and weight gain. Weight gain during valproate treatment can be observed within the …

Epilepsy is a chronic neurological disease characterized by recurrent seizures. Epilepsy is
observed as a well‐controlled disease by anti‐epileptic agents (AEAs) in about 69 …

Several major developments have occurred since the last edition of Handbook of Obesity:
Clinical Applications, including new clinical trials, discoveries related to drug use, and …

Valproate (2-propylpentanoate) is available as valproic acid, sodium valproate and
semisodium valproate. It has actions on dopamine, GABA and glutamate neurotransmission …

Purpose: Long‐term antiepileptic drug (AED) therapy has been associated with an increase
in risk of atherosclerosis. At issue is whether this risk is related to the duration of AED …

Obesity, defined as having a body mass index (BMI) greater than 30 kg/m 2, has been
verified to be associated with several health problems which are always grouped as …

It is well established that overweight/obesity is closely associated with multiple health
problems. Among these, dyslipidemia is the most important and main driving force behind …

Opinion statement The most-used treatments for epilepsy worldwide are older-generation
drugs such as phenytoin, carbamazepine, phenobarbital, and valproic acid, which have …

Valproic acid (VPA) is considered to be a drug of first choice and one of the most frequently-
prescribed antiepileptic drugs worldwide for the therapy of generalized and focal epilepsies …