Cell signaling does not apparently occur randomly over the cell surface, but it seems to be
integrated very often into cholesterol-rich membrane domains, termed lipid rafts. Membrane …

The malignant transformation of cells requires adaptations across multiple metabolic
processes to satisfy the energy required for their increased rate of proliferation …

Background/Aims: Elevated serum cholesterol levels were linked to a higher risk of
colorectal adenoma and colorectal cancer (CRC), while the effect of cholesterol on CRC …

Rhubarb has been used as a traditional Chinese medicine since ancient times and today it
is still present in various herbal preparations. In this review the toxicological and anti …

Lipid rafts/caveolae are membrane platforms for signaling molecules that regulate various
cellular functions, including cell survival. To better understand the role of rafts in tumor …

Prostate cancer (PCa) metabolism appears to be unique in comparison with other types of
solid cancers. Normal prostate cells mainly rely on glucose oxidation to provide precursors …

Lipid rafts are cholesterol-and sphingolipid-enriched microdomains in cell membranes that
regulate phosphorylation cascades originating from membrane-bound proteins. In this study …

Prostate cancer risk can be modified by environmental factors, however the molecular
mechanisms affecting susceptibility to this disease are not well understood. As a result of a …

Abstract Protein kinase B (PKB/Akt) has been shown to play a role in protection from
apoptosis, cell proliferation and cell growth. It is also involved in mediating the effects of …

Purpose: Prostate cancer eventually recurs during androgen deprivation therapy despite
castrate levels of serum androgens. Expression of androgen receptor and androgen …