Aptamers as diagnostic tools in cancer
D Ruiz Ciancio, MR Vargas, WH Thiel, MA Bruno… - Pharmaceuticals, 2018 - mdpi.com
Cancer is the second leading cause of death worldwide. Researchers have been working
hard on investigating not only improved therapeutics but also on early detection methods …
hard on investigating not only improved therapeutics but also on early detection methods …
Recent advances in cancer early detection and diagnosis: Role of nucleic acid based aptasensors
EM Hassan, MC DeRosa - TrAC Trends in Analytical Chemistry, 2020 - Elsevier
Cancer is a complex disease of worldwide concern. Along with an improvement in
outcomes, early and sensitive detection of cancer and cancer biomarkers can facilitate an …
outcomes, early and sensitive detection of cancer and cancer biomarkers can facilitate an …
Spontaneous mutations in the single TTN gene represent high tumor mutation burden
Tumor mutation burden (TMB) is an emerging biomarker, whose calculation requires
targeted sequencing of many genes. We investigated if the measurement of mutation counts …
targeted sequencing of many genes. We investigated if the measurement of mutation counts …
Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins
The intracellular pH (pHi) of most cancers is constitutively higher than that of normal cells
and enhances proliferation and cell survival. We found that increased pHi enabled the …
and enhances proliferation and cell survival. We found that increased pHi enabled the …
Proteoglycans: a common portal for SARS-CoV-2 and extracellular vesicle uptake
M Cerezo-Magaña… - American Journal of …, 2023 - journals.physiology.org
As structural components of the glycocalyx, heparan sulfate proteoglycans (HSPGs) are
involved in multiple pathophysiological processes at the apex of cell signaling cascades …
involved in multiple pathophysiological processes at the apex of cell signaling cascades …
[HTML][HTML] Characterization of potential driver mutations involved in human breast cancer by computational approaches
BK Rajendran, CX Deng - Oncotarget, 2017 - ncbi.nlm.nih.gov
Breast cancer is the second most frequently occurring form of cancer and is also the second
most lethal cancer in women worldwide. A genetic mutation is one of the key factors that …
most lethal cancer in women worldwide. A genetic mutation is one of the key factors that …
Integrative statistical analyses of multiple liquid biopsy analytes in metastatic breast cancer
C Keup, V Suryaprakash, S Hauch, M Storbeck… - Genome Medicine, 2021 - Springer
Background Single liquid biopsy analytes (LBAs) have been utilized for therapy selection in
metastatic breast cancer (MBC). We performed integrative statistical analyses to examine …
metastatic breast cancer (MBC). We performed integrative statistical analyses to examine …
[HTML][HTML] Selective targeting of the oncogenic KRAS G12S mutant allele by CRISPR/Cas9 induces efficient tumor regression
Q Gao, W Ouyang, B Kang, X Han, Y Xiong, R Ding… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: KRAS is one of the most frequently mutated oncogenes in cancers. The protein's
picomolar affinity for GTP/GDP and smooth protein structure resulting in the absence of …
picomolar affinity for GTP/GDP and smooth protein structure resulting in the absence of …
Pan-cancer analysis on microRNA-associated gene activation
Abstract Background While microRNAs (miRNAs) were widely considered to repress target
genes at mRNA and/or protein levels, emerging evidence from in vitro experiments has …
genes at mRNA and/or protein levels, emerging evidence from in vitro experiments has …
Targeted sequencing of plasma-derived vs. urinary cfDNA from patients with triple-negative breast cancer
H Herzog, S Dogan, B Aktas, I Nel - Cancers, 2022 - mdpi.com
Simple Summary Circulating cell-free DNA displays vast potential to capture the entire
genetic landscape of a tumor and to characterize intratumoral heterogeneity, providing a …
genetic landscape of a tumor and to characterize intratumoral heterogeneity, providing a …