Aptamers as diagnostic tools in cancer

D Ruiz Ciancio, MR Vargas, WH Thiel, MA Bruno… - Pharmaceuticals, 2018 - mdpi.com
Cancer is the second leading cause of death worldwide. Researchers have been working
hard on investigating not only improved therapeutics but also on early detection methods …

Recent advances in cancer early detection and diagnosis: Role of nucleic acid based aptasensors

EM Hassan, MC DeRosa - TrAC Trends in Analytical Chemistry, 2020 - Elsevier
Cancer is a complex disease of worldwide concern. Along with an improvement in
outcomes, early and sensitive detection of cancer and cancer biomarkers can facilitate an …

Spontaneous mutations in the single TTN gene represent high tumor mutation burden

JH Oh, SJ Jang, J Kim, I Sohn, JY Lee, EJ Cho… - NPJ genomic …, 2020 - nature.com
Tumor mutation burden (TMB) is an emerging biomarker, whose calculation requires
targeted sequencing of many genes. We investigated if the measurement of mutation counts …

Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins

KA White, DG Ruiz, ZA Szpiech, NB Strauli… - Science …, 2017 - science.org
The intracellular pH (pHi) of most cancers is constitutively higher than that of normal cells
and enhances proliferation and cell survival. We found that increased pHi enabled the …

Proteoglycans: a common portal for SARS-CoV-2 and extracellular vesicle uptake

M Cerezo-Magaña… - American Journal of …, 2023 - journals.physiology.org
As structural components of the glycocalyx, heparan sulfate proteoglycans (HSPGs) are
involved in multiple pathophysiological processes at the apex of cell signaling cascades …

[HTML][HTML] Characterization of potential driver mutations involved in human breast cancer by computational approaches

BK Rajendran, CX Deng - Oncotarget, 2017 - ncbi.nlm.nih.gov
Breast cancer is the second most frequently occurring form of cancer and is also the second
most lethal cancer in women worldwide. A genetic mutation is one of the key factors that …

Integrative statistical analyses of multiple liquid biopsy analytes in metastatic breast cancer

C Keup, V Suryaprakash, S Hauch, M Storbeck… - Genome Medicine, 2021 - Springer
Background Single liquid biopsy analytes (LBAs) have been utilized for therapy selection in
metastatic breast cancer (MBC). We performed integrative statistical analyses to examine …

[HTML][HTML] Selective targeting of the oncogenic KRAS G12S mutant allele by CRISPR/Cas9 induces efficient tumor regression

Q Gao, W Ouyang, B Kang, X Han, Y Xiong, R Ding… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: KRAS is one of the most frequently mutated oncogenes in cancers. The protein's
picomolar affinity for GTP/GDP and smooth protein structure resulting in the absence of …

Pan-cancer analysis on microRNA-associated gene activation

H Tan, S Huang, Z Zhang, X Qian, P Sun, X Zhou - EBioMedicine, 2019 - thelancet.com
Abstract Background While microRNAs (miRNAs) were widely considered to repress target
genes at mRNA and/or protein levels, emerging evidence from in vitro experiments has …

Targeted sequencing of plasma-derived vs. urinary cfDNA from patients with triple-negative breast cancer

H Herzog, S Dogan, B Aktas, I Nel - Cancers, 2022 - mdpi.com
Simple Summary Circulating cell-free DNA displays vast potential to capture the entire
genetic landscape of a tumor and to characterize intratumoral heterogeneity, providing a …