Monogenic diabetes refers to diabetes mellitus (DM) caused by a mutation in a single gene
and accounts for approximately 1%–5% of diabetes. Correct diagnosis is clinically critical for …

Congenital hypothyroidism occurs in approximately 1 in 2000 newborns and can have
devastating neurodevelopmental consequences if not detected and treated promptly. While …

Krüppel-like zinc finger proteins form one of the largest families of transcription factors. They
function as key regulators of embryonic development and a wide range of other …

ABSTRACT GLI-Similar 3 (GLIS3) is a member of the GLIS subfamily of Krüppel-like zinc
finger transcription factors that functions as an activator or repressor of gene expression …

In pleiotropic diseases, multiple organ systems are affected causing a variety of clinical
manifestations. Here, we report a pleiotropic disorder with a unique constellation of …

Recent studies have provided evidence for a regulatory role of GLI-similar (GLIS)
transcription factors in reprogramming, maintenance and differentiation of several stem and …

Understanding of pancreatic islet biology has greatly increased over the past few decades
based in part on an increased understanding of the transcription factors that guide this …

Previous reviews and clinical guidelines have identified 10–20 genetic syndromes
associated with diabetes, but no systematic review has been conducted to date. We provide …

Objectives Defects in the human GLI-similar 3 (GLIS3) gene are reported to be a rare cause
of congenital hypothyroidism (CH) and neonatal diabetes. The aim of this study was to …

Objective While most of the variation in thyroid function is determined by genetic factors,
single nucleotide polymorphisms (SNPs) identified via genome-wide association analyses …