CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Inflammation is an adaptive response in pursuit of homeostasis reestablishment triggered by
harmful conditions or stimuli, such as an infection or tissue damage. Liver diseases cause …

The roles of Rev-erbα and circadian clock in colonic inflammation remain unclarified. Here
we show colon clock genes (including Rev-erbα) are dysregulated in mice with DSS …

Cancer is a leading cause of death worldwide. Cancer cells proliferate uncontrollably and,
many cases, spread to other parts of the body. A protein historically involved in cancer is …

Protein kinase CK2, a protein serine/threonine kinase, plays a global role in activities related
to cell growth, cell death, and cell survival. CK2 has a large number of potential substrates …

The term 'casein kinase'has been widely used for decades to denote protein kinases sharing
the ability to readily phosphorylate casein in vitro. These fall into three main classes: two of …

Abstract Protein kinase CSNK2 (CK2) is a pleiotropic serine/threonine kinase frequently
dysregulated in solid and hematologic malignancies. To consolidate a wide range of …

Diosgenin is a precursor of steroid hormones, which can be found in several plant species.
Diosgenin has been shown to have a variety of biological activities including anti …

Introduction: The conventional term 'casein kinase'(CK) denotes three classes of kinases–
CK1, CK2 and Golgi-CK (G-CK)/Fam20C (family with sequence similarity 20, member C) …

ABSTRACT RIG-I is an intracellular RNA virus sensor that mediates a signaling pathway that
triggers the alpha/beta interferon (IFN-α/β) immune defenses. However, the mechanism for …